L-Thyroxine

CAS 51-48-9HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2HCell Biology

L-Thyroxine (CAS: 51-48-9), a key iodinated thyronine, is vital for mammalian metabolism. With the molecular formula HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H and a molecular weight of 776.87 g/mol, it functions as a thyroid hormone. Primarily utilised in biological research, it serves as a reagent in cell biology and cell culture studies, supporting investigations into metabolic processes and endocrine functions.

IUPAC: 3,3′,5,5″-Tetraiodo-L-thyronine,3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine,T4
Synonyms: 3,3′,5,5″-Tetraiodo-L-thyronine3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanineT4

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L-Thyroxine (HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H) — chemical structure, CAS 51-48-9; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyCell CultureHormonesReagents and SupplementsT More...

01 /Applications

Cell Biology Research

L-Thyroxine is extensively employed in cell biology for studying thyroid hormone receptor interactions and downstream cellular signalling pathways. Its role in regulating gene expression makes it invaluable for understanding cellular differentiation and function.

Cell Culture Supplementation

As a supplement in cell culture media, L-Thyroxine supports the growth and maintenance of specific cell lines, particularly those dependent on thyroid hormone signalling. This aids in in-vitro models of physiological processes.

Biochemical Assays

The compound serves as a standard or reagent in various biochemical assays designed to investigate enzyme kinetics, hormone metabolism, and drug interactions within biological systems. Its defined purity ensures reliable experimental results.

02 /Properties

Molecular weight	776.87
Linear formula	HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
Assay	≥98% (HPLC)
Form	powder
Melting point	223 °C (dec.)(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

51-48-9

MDL number

MFCD00002595

PubChem substance

24899990

Beilstein registry

2228515

05 /Additional specifications

Product Line	BioReagent
Gene Information	human ... TTR(7276)mouse ... Cnr2(12802)rat ... Cnr1(25248)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is L-Thyroxine used for?

L-Thyroxine is primarily used in biological research, specifically in cell biology and cell culture, as a reagent to study metabolic processes and endocrine functions.

What is the CAS number and formula for L-Thyroxine?

The CAS number for L-Thyroxine is 51-48-9, and its linear formula is HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies L-Thyroxine with an assay of ≥98% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmaceutical grade.

How should L-Thyroxine be handled safely?

When handling L-Thyroxine, it is essential to wear safety glasses, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It is classified under WGK Germany 2, indicating it is hazardous to water.

Is L-Thyroxine a controlled substance?

Based on the provided data, L-Thyroxine (CAS 51-48-9) is not indicated as a controlled substance. However, users should always consult local regulations.

How is L-Thyroxine shipped and exported?

L-Thyroxine is supplied as a powder and is exported globally by Tech Serve Solutions. Specific packaging and shipping details are available upon request.

How can I request a sample or quote for L-Thyroxine?

To request a sample or quote for L-Thyroxine, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.