K-Oxyma
K-Oxyma (CAS: 158014-03-0; Formula: C5H5KN2O3; MW: 180.20) is a potassium salt widely recognised as a highly effective and non-explosive alternative to HOBt and HOAt in peptide synthesis. It exhibits superior performance, particularly in sterically hindered couplings and fragment condensations, while minimising epimerisation. Its properties make it suitable for various peptide coupling strategies, including solution and solid-phase methods.
- IUPAC
- 2-Cyano-2-(hydroxyimino)acetic acid ethyl ester, potassium salt,Ethyl (hydroxyimino)cyanoacetate potassium salt
- Synonyms
- 2-Cyano-2-(hydroxyimino)acetic acid ethyl ester, potassium saltEthyl (hydroxyimino)cyanoacetate potassium salt
Peptide Bond Formation
K-Oxyma serves as a superior additive for carbodiimide-mediated peptide coupling, offering improved efficiency and reduced epimerisation compared to traditional additives like HOBt, especially in challenging synthetic routes.
Fragment Condensation
This reagent excels in fragment condensation reactions, providing a more controlled coupling process with significantly less epimerisation, ensuring higher purity of the final peptide sequence.
Solid-Phase Peptide Synthesis (SPPS)
Its compatibility with mild acid-labile resins, such as 2-chlorotrityl, is a key advantage in SPPS. The K-salt form offers enhanced stability and prevents premature cleavage of the peptide from the resin.
Sterically Hindered Couplings
K-Oxyma demonstrates enhanced performance over HOAt in coupling sterically demanding amino acids, facilitating the synthesis of complex peptide structures that are otherwise difficult to achieve.
| Molecular weight | 180.20 |
|---|---|
| Empirical formula | C5H5KN2O3 |
| Assay | 97% |
| Storage temperature | 2-8°C |
| Application | • Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt• Outperforms HOAt in sterically demanding peptide bond formations• Compatible with carbodiimide-mediated; solution and solid phase peptide coupling;• Less epimerization than HOBt in fragment condensation reactions• K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character• K-salt has a higher melting point than OxymaPure |
| Melting point | 141-147 |
Hazard statements
- H301Toxic if swallowed
- H312Harmful in contact with skin
- H317May cause an allergic skin reaction
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
| Transport (UN / ADR) | UN 3439 6.1 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 20/21-25-43 |
| Safety statements (S) | 36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is K-Oxyma used for?
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K-Oxyma is primarily used as a non-explosive additive in peptide synthesis, particularly for carbodiimide-mediated couplings, fragment condensations, and solid-phase peptide synthesis, where it offers improved efficiency and reduced epimerisation.
What is the CAS number and formula for K-Oxyma?
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The CAS number for K-Oxyma is 158014-03-0, and its empirical formula is C5H5KN2O3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies K-Oxyma with a minimum assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade; it is supplied for research and laboratory use.
How should K-Oxyma be handled safely?
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K-Oxyma is classified as toxic if swallowed, harmful in contact with skin and if inhaled, and may cause an allergic skin reaction. It requires careful handling in a well-ventilated area, using appropriate personal protective equipment (gloves, protective clothing, eye/face protection) to avoid exposure. Refer to the Safety Data Sheet for detailed information.
How is K-Oxyma packed, shipped, and exported?
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K-Oxyma is packaged according to industry best practices for chemical reagents and can be shipped and exported globally by Tech Serve Solutions, adhering to all relevant transport regulations for hazardous materials (UN 3439, Class 6.1).
How can I request a sample or quote for K-Oxyma?
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To request a sample or a quote for K-Oxyma, please contact our sales team via the website or by telephone, providing your contact details and the quantity required.
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