Isopropylboronic acid
Isopropylboronic acid (CAS: 80041-89-0), with the linear formula (CH3)2CHB(OH)2 and a molecular weight of 87.91 g/mol, is an organoboron compound. It serves as a valuable reagent in organic synthesis, particularly for copper-promoted cross-coupling reactions, C-H activation for arylations and alkylations, and Suzuki-Miyaura type coupling reactions. This compound is essential for building complex molecular architectures in chemical research and development.
- IUPAC
- (1-Methylethyl)boronic acid,(Propan-2-yl)boronic acid,2-Propaneboronic acid
- Synonyms
- (1-Methylethyl)boronic acid(Propan-2-yl)boronic acid2-Propaneboronic acid
Suzuki-Miyaura Coupling Reactions
Isopropylboronic acid is a key coupling partner in Suzuki-Miyaura reactions, enabling the formation of carbon-carbon bonds. This widely used synthetic methodology is crucial for constructing biaryl compounds and other complex organic structures.
C-H Activation for Arylations and Alkylations
This boronic acid facilitates C-H activation processes, allowing for direct functionalisation of C-H bonds. This approach offers an efficient route for introducing alkyl or aryl groups into organic molecules, streamlining synthetic pathways.
Domino Heck-Suzuki Reactions
It participates in domino Heck-Suzuki reactions, where multiple bond-forming events occur sequentially in a single reaction vessel. This cascade approach enhances synthetic efficiency and atom economy.
Copper-Promoted Cross-Coupling
Isopropylboronic acid is employed as a substrate in copper-promoted cross-coupling reactions, contributing to the synthesis of various organic compounds. These reactions are vital in pharmaceutical and materials science research.
| Molecular weight | 87.91 |
|---|---|
| Linear formula | (CH3)2CHB(OH)2 |
| Application | Reactant or reagent involved in:• Copper-promoted cross-coupling1• Domino Heck-Suzuki reactions2• C-H activation for arylations and alkylations3• Suzuki-Miyaura type couple reactions4• Alkylation-hydride reduction sequence5 |
| Melting point | 95-100 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Isopropylboronic acid used for?
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Isopropylboronic acid is primarily used as a reactant or reagent in various organic synthesis applications, including copper-promoted cross-coupling, domino Heck-Suzuki reactions, C-H activation for arylations and alkylations, Suzuki-Miyaura type couple reactions, and alkylation-hydride reduction sequences.
What is the CAS number and chemical formula for Isopropylboronic acid?
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The CAS number for Isopropylboronic acid is 80041-89-0, and its linear formula is (CH3)2CHB(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Isopropylboronic acid typically as a research or technical grade chemical. The exact purity and assay are detailed on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for Isopropylboronic acid?
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When handling Isopropylboronic acid, it is essential to wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Refer to the Safety Data Sheet (SDS) for comprehensive hazard information and handling procedures.
How is Isopropylboronic acid shipped and exported?
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Isopropylboronic acid is carefully packed and exported by Tech Serve Solutions in compliance with all relevant shipping and regulatory requirements for chemical substances. Please contact us for specific shipping details and international export capabilities.
How can I request a sample or quote for Isopropylboronic acid?
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To request a sample or a quote for Isopropylboronic acid, please visit the product page on the Tech Serve Solutions website and use the designated inquiry form, or contact our sales team directly via email or phone.
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