Iodoacetic anhydride
Iodoacetic anhydride (CAS: 54907-61-8), with the linear formula (ICH₂CO)₂O and a molecular weight of 353.88 g/mol, is a reactive chemical compound utilised in organic synthesis. It serves as a key reagent for introducing the iodoacetyl group in various chemical transformations. This anhydride is particularly valuable for linking functional groups, especially in biochemical research for protein modification and the synthesis of specific chemical derivatives.
Protein Modification and Quantitation
Iodoacetic anhydride acts as a linker reagent for the development of tools used in differential protein quantitation through ion scanning techniques, enabling researchers to study protein modifications.
Synthesis of Glycosylamine Derivatives
This compound is a key reactant in the synthesis of N-iodoacetyl glycosylamine derivatives, a process vital for creating specific carbohydrate-based molecules for research.
Peptide and Amine Functionalisation
It is employed for linking lysine residues to the N-terminal alpha-amino groups of peptides and for capping amines, yielding thiol-reactive iodo-derivatives essential in biochemical studies.
General Iodoacetylation
Iodoacetic anhydride is broadly applied in iodoacetylation reactions, a fundamental transformation in organic and medicinal chemistry for modifying various organic molecules.
| Molecular weight | 353.88 |
|---|---|
| Linear formula | (ICH2CO)2O |
| Solubility | chloroform: soluble10%, clear to slightly hazy, yellow (pink or tan) |
| Storage temperature | 2-8°C |
| Application | Reagent used as linker for development of reagents used for differential protein quantitation via ion scanning1Reactant used for:• Sythesis of N-iodoacetyl glycosylamine derivatives2 and converting amino precursors to IA derivatives3• Linking lysine residues to N-terminal α-amino groups of peptides4• Capping amines and yielding a thiol reactive iodo-derivative5• Iodoacetylation6 |
| Melting point | 47-49 °C(lit.) |
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | 110 °C / 230 °F |
|---|---|
| Transport (UN / ADR) | UN 3261 8/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,C |
| Risk statements (R) | 25-35 |
| Safety statements (S) | 22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Iodoacetic anhydride used for?
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Iodoacetic anhydride is used as a reagent for differential protein quantitation, synthesis of N-iodoacetyl glycosylamine derivatives, linking lysine residues to peptides, capping amines, and general iodoacetylation reactions.
What are the CAS number and formula for Iodoacetic anhydride?
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The CAS number for Iodoacetic anhydride is 54907-61-8, and its linear formula is (ICH₂CO)₂O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Iodoacetic anhydride as a research-grade chemical. We do not represent this product as USP, BP, or EP.
How should I safely handle and store Iodoacetic anhydride?
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Iodoacetic anhydride is classified as Toxic and Corrosive. Handle with appropriate personal protective equipment (gloves, eye protection, protective clothing) in a well-ventilated area. Store at 2-8°C. Refer to the Safety Data Sheet for comprehensive safety information.
Is Iodoacetic anhydride a controlled substance?
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The provided data does not indicate that Iodoacetic anhydride is a controlled substance.
How is Iodoacetic anhydride packed and shipped?
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Iodoacetic anhydride is packed and shipped according to international regulations for hazardous materials, including UN 3261 classification.
How can I request a quote or sample for Iodoacetic anhydride?
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Please contact the TSS sales team via our website or direct inquiry to request a quote or sample for Iodoacetic anhydride.
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