Hexamethylphosphoramide

CAS 680-31-9[(CH3)2N]3POChemical Synthesis

Hexamethylphosphoramide (CAS: 680-31-9), with the molecular formula [(CH3)2N]3PO and a molar mass of 179.20 g/mol, is a versatile aprotic solvent. Its unique properties make it valuable in various chemical synthesis applications. Tech Serve Solutions provides this compound, noted for its solvent capabilities, to support research and industrial processes requiring specific reaction media.

IUPAC: HMPA,Hexamethylphosphoric acid triamide,Tris(dimethylamino)phosphine oxide
Synonyms: HMPAHexamethylphosphoric acid triamideTris(dimethylamino)phosphine oxide

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Hexamethylphosphoramide ([(CH3)2N]3PO) — chemical structure, CAS 680-31-9; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisCouplingOthersSynthetic Reagents

01 /Applications

Aprotic Solvent

Hexamethylphosphoramide serves as a highly polar aprotic solvent. It is effective in facilitating reactions that require the solvation of cations while leaving anions relatively free and reactive.

Chemical Synthesis Reagent

This compound is employed as a reagent and solvent in a variety of organic syntheses. Its properties can influence reaction rates and selectivities in complex chemical transformations.

Coupling Reactions

Hexamethylphosphoramide can be used to promote or facilitate certain coupling reactions. Its solvating ability assists in bringing reactants together and stabilising intermediates.

02 /Properties

Molecular weight	179.20
Linear formula	[(CH3)2N]3PO
Assay	99%
Boiling point	230-232 °C/740 mmHg(lit.)
Density	1.03 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.459(lit.)
Vapour pressure	0.07 mmHg (25 °C)
Melting point	7 °C(lit.)
Vapour density	6.18 (vs air)
Application	Useful aprotic solvent.

03 /Safety & handling

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H340May cause genetic defects
H350May cause cancer

Precautionary statements

P201Obtain special instructions before use
P308IF exposed or concerned

Protective equipment	Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	144 °C / 291.2 °F
Transport (UN / ADR)	UN 3082 9 / PGIII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	45-46
Safety statements (S)	53-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

680-31-9

MDL number

MFCD00008303

PubChem substance

24895433

Beilstein registry

1099903

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Hexamethylphosphoramide used for?

Hexamethylphosphoramide (CAS: 680-31-9) is primarily used as a polar aprotic solvent and reagent in chemical synthesis, particularly for coupling reactions and other organic transformations where its unique solvating properties are beneficial.

What is the CAS number and formula for Hexamethylphosphoramide?

The CAS number for Hexamethylphosphoramide is 680-31-9, and its molecular formula is [(CH3)2N]3PO.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Hexamethylphosphoramide with an assay of 99%. This product is supplied for laboratory and industrial use and is not represented as USP, BP, EP, or other pharmacopoeia grades.

What are the main safety concerns when handling Hexamethylphosphoramide?

Hexamethylphosphoramide is classified with GHS08, indicating significant health hazards. It carries the signal word 'Danger' with hazard statements H340 (May cause genetic defects) and H350 (May cause cancer). Appropriate personal protective equipment, including eyeshields and gloves, and engineering controls are essential for safe handling.

How is Hexamethylphosphoramide shipped?

Hexamethylphosphoramide is classified under UN 3082, 9/PGIII for transport. We ensure all shipments comply with relevant international regulations for hazardous materials.

How can I request a quote or sample for Hexamethylphosphoramide?

To request a quote or sample of Hexamethylphosphoramide, please contact our sales team through the website or by phone. Our representatives will be pleased to assist you with your specific requirements.