Glycerol formal
Glycerol formal (CAS: 99569-11-6, C4H8O3, MW: 104.10) is a versatile chemical utilized for its excellent solvency properties. It effectively solubilises water-insoluble compounds, facilitating their subsequent dilution in aqueous systems. Glycerol formal serves as a valuable cosolvent in drug delivery applications and functions as a chemical and dye emulsifier. Its ability to act as a vehicle for compound delivery makes it a useful component in various chemical syntheses and formulations.

Solubilisation of Water-Insoluble Compounds
Glycerol formal is employed to dissolve substances that are not readily soluble in water. This property is crucial for preparing homogeneous solutions for further processing or application.
Chemical and Dye Emulsifier
It functions as an effective emulsifier in chemical and dye industries, aiding in the formation of stable mixtures between immiscible liquids.
Cosolvent for Drug Delivery
Glycerol formal has been utilised as a cosolvent in drug delivery systems. Its properties allow for the formulation of poorly soluble active pharmaceutical ingredients.
Vehicle for Compound Delivery
Historically, glycerol formal has been used as a vehicle for the delivery of specific compounds, such as antibiotics, in research settings.
| Molecular weight | 104.10 |
|---|---|
| Empirical formula | C4H8O3 |
| Assay | ≥98.0% (GC) |
| Boiling point | 192-193 °C(lit.) |
| Density | 1.203 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.451(lit.)n20/D 1.451 |
| Contains / stabiliser | ~0.02% 2,6-di-tert-butyl-4-methylphenol as stabilizer |
| Application | Glycerol formal is used to to solubilize water-insoluble compounds for subsequent aqueous dilution. It has been used as a chemical and dye emulsifier and as a cosolvent for drug delivery1. Glycerol formal was used as a vehicle for antibiotic delivery in rats.2 |

Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 93 °C / 199.4 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Glycerol formal primarily used for?
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Glycerol formal is primarily used to solubilise water-insoluble compounds for subsequent aqueous dilution, as a chemical and dye emulsifier, and as a cosolvent for drug delivery.
What is the CAS number and formula for Glycerol formal?
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The CAS number for Glycerol formal is 99569-11-6, and its empirical formula is C4H8O3.
What grade and purity does Tech Serve Solutions supply for Glycerol formal?
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Tech Serve Solutions supplies Glycerol formal with an assay of ≥98.0% (GC). We do not represent this product as USP, BP, EP, or any pharmacopoeia grade unless explicitly stated in the product data.
How should Glycerol formal be handled safely?
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Glycerol formal is classified with GHS07 and a Warning signal word, carrying the hazard statement H319 (Causes serious eye irritation). Handle with appropriate personal protective equipment, including eyeshields and gloves. Ensure adequate ventilation and use a suitable respirator if needed.
Does Tech Serve Solutions export Glycerol formal?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Glycerol formal.
How can I request a sample or quote for Glycerol formal?
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Please contact our sales team directly via the website or your designated account manager to request a sample or quote for Glycerol formal.
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