Gemcitabine hydrochloride
Gemcitabine hydrochloride (CAS: 122111-03-9), with the molecular formula C9H11F2N3O4 · HCl and a molecular weight of 299.66 g/mol, is a difluorinated nucleoside analogue. It functions as an antimetabolite, primarily incorporated into DNA, leading to DNA strand breaks and apoptosis. This compound is widely recognised for its therapeutic applications in oncology, particularly in the treatment of various solid tumours, where it plays a crucial role in chemotherapy regimens.
- IUPAC
- 2′-Deoxy-2′,2′-difluorocytidine; dFdC,Gemzar (Lilly),LY-188011,dFdC,dFdCyd
- Synonyms
- 2′-Deoxy-2′,2′-difluorocytidinedFdC,Gemzar (Lilly),LY-188011,dFdC,dFdCyd
Oncology Therapeutics
Gemcitabine hydrochloride is a cornerstone chemotherapeutic agent used in the treatment of several types of cancer, including pancreatic, lung, ovarian, and breast cancer. Its mechanism involves inhibiting DNA synthesis and inducing programmed cell death (apoptosis) in rapidly dividing cancer cells.
Apoptosis Research
As a potent inducer of apoptosis, gemcitabine hydrochloride is utilized in research settings to study cell death pathways. It serves as a valuable tool for investigating the molecular mechanisms underlying cancer progression and the efficacy of various treatment strategies.
Cell Cycle Regulation Studies
This compound interferes with DNA replication and cell division, making it relevant for research into cell cycle regulation. Scientists use gemcitabine hydrochloride to explore how disruptions in the cell cycle contribute to disease states and to identify potential therapeutic targets.
| Molecular weight | 299.66 |
|---|---|
| Empirical formula | C9H11F2N3O4 · HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Solubility | H2O: ≥10 mg/mL |
| Storage temperature | room temp |
Hazard statements
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P308IF exposed or concerned
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 63-62 |
| Safety statements (S) | 53-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Storage Condition | desiccatedprotect from light |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Gemcitabine hydrochloride used for?
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Gemcitabine hydrochloride is primarily used as a chemotherapeutic agent for treating various solid tumours, including pancreatic, lung, ovarian, and breast cancer. It is also used in research to study apoptosis and cell cycle regulation.
What is the CAS number and formula for Gemcitabine hydrochloride?
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The CAS number for Gemcitabine hydrochloride is 122111-03-9, and its empirical formula is C9H11F2N3O4 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Gemcitabine hydrochloride with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling requirements for Gemcitabine hydrochloride?
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Gemcitabine hydrochloride is classified as Danger (GHS08) and carries the hazard statement H360, indicating it may damage fertility or the unborn child. It should be handled with extreme caution, particularly by individuals of reproductive age. P201 and P308 + P313 precautionary statements apply, requiring users to obtain prior instructions and seek medical attention if exposed or concerned.
How is Gemcitabine hydrochloride typically shipped and exported?
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Gemcitabine hydrochloride is typically supplied as a powder and shipped at room temperature. It requires storage in a desiccated and light-protected environment. As a global supplier, Tech Serve Solutions facilitates the export of this chemical worldwide.
How can I request a quote or sample for Gemcitabine hydrochloride?
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To request a quote or a sample of Gemcitabine hydrochloride, please contact our sales team through the website or directly via email, providing your specific requirements.
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