Folinic acid calcium salt hydrate
Folinic acid calcium salt hydrate (CAS: 1492-18-8) is a hydrated calcium salt form of folinic acid, a derivative of folic acid. With the empirical formula C20H21CaN7O7 · xH2O and a molecular weight of 511.50 (anhydrous basis), this compound plays a critical role in biological systems. It is primarily recognised for its medical applications in counteracting folic acid antagonists and potentiating the effects of certain chemotherapeutic agents. It is essential for various cellular processes.
- IUPAC
- 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt,5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt,5-HCO-H4PteGlu,Calcium folinate,Citrovorum factor calcium salt,Leucovorin calcium salt
- Synonyms
- 5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt5-HCO-H4PteGluCalcium folinateCitrovorum factor calcium saltLeucovorin calcium salt
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Counteracting Folic Acid Antagonists
Calcium folinate is used to mitigate the effects of drugs that inhibit dihydrofolate reductase, a key enzyme in folic acid metabolism. This is crucial in medical treatments where such antagonists are employed.
Methotrexate Toxicity Reduction
Following treatment with methotrexate, calcium folinate serves as a rescue agent. It helps to reduce the toxic side effects of methotrexate by restoring normal folate levels.
Enhancing Chemotherapy Efficacy
In cancer treatment, calcium folinate is employed to potentiate the cytotoxic effects of 5-fluorouracil. This synergistic action improves the overall effectiveness of the chemotherapy regimen.
Cell Biology Research
As a derivative of folic acid, this compound is relevant in cell biology studies focusing on folate metabolism, DNA synthesis, and cell proliferation. Its role as a coenzyme makes it valuable for in vitro research.
| Molecular weight | 511.50 (anhydrous basis) |
|---|---|
| Empirical formula | C20H21CaN7O7 · xH2O |
| Application | Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer. |
Hazard statements
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H334May cause allergy or asthma symptoms if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P342
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/37/38-42/43 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Folinic acid calcium salt hydrate used for?
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Folinic acid calcium salt hydrate is used medically to offset the effects of folic acid antagonists, reduce methotrexate toxicity, and enhance the efficacy of 5-fluorouracil in cancer treatment. It also finds applications in cell biology and nutrition research.
What are the CAS number and formula for Folinic acid calcium salt hydrate?
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The CAS number for the anhydrous form is 1492-18-8. The empirical formula is C20H21CaN7O7 · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Folinic acid calcium salt hydrate for research and laboratory use. The specific assay and purity are detailed in the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
How should Folinic acid calcium salt hydrate be handled?
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Handling requires caution due to potential respiratory and skin sensitisation, as well as eye and respiratory irritation (H315, H317, H319, H334, H335). Use a P261-rated dust mask, safety eyeshields, face shields, and gloves. Ensure adequate ventilation and avoid breathing dust.
How is this product packed and exported?
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Products are carefully packed according to international shipping regulations to ensure integrity during transit. Tech Serve Solutions is experienced in exporting fine chemicals globally.
How can I request a sample or quote?
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To request a sample or obtain a quotation, please visit the product page on our website and use the designated 'Request Sample' or 'Enquire' button, or contact our sales team directly.
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