Ethyl propiolate
Ethyl propiolate (CAS 623-47-2), with the formula HC≡CCO₂C₂H₅ and a molar mass of 98.10 g/mol, is a valuable organic building block and ester. This compound serves as a versatile reagent in various chemical syntheses, particularly in the preparation of more complex organic molecules. Its utility is noted in reactions involving asymmetric alkynylation and multi-component syntheses. Tech Serve Solutions supplies Ethyl propiolate for research and development purposes.
- IUPAC
- Ethyl acetylenecarboxylate
Substrate for Asymmetric Alkynylation
Halogenated derivatives of ethyl propiolate have been employed as substrates in the direct, asymmetric alkynylation of cyclic β-ketoesters. This application often utilises chiral phase-transfer catalysts to achieve the desired stereoselectivity.
Reagent in Multi-Component Syntheses
Ethyl propiolate can participate in one-pot, four-component reactions. For instance, it has been used in the synthesis of benzene-1,2,3,5-tetracarboxylates, typically promoted by triphenylphosphine.
Organic Synthesis Building Block
As an ester and an alkyne, ethyl propiolate is a fundamental building block for creating a wide array of organic compounds. Its functional groups allow for diverse synthetic transformations in medicinal chemistry and materials science research.
| Molecular weight | 98.10 |
|---|---|
| Linear formula | HC≡CCO2C2H5 |
| Assay | 99% |
| Boiling point | 120 °C(lit.) |
| Density | 0.968 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.412(lit.) |
| Storage temperature | 2-8°C |
| Application | Halogenated derivatives were used as substrates for direct, asymmetric alkynylation of cyclic ß-ketoesters using chiral phase-transfer catalysts.1 Also employed in a one-pot , four-component synthesis of benzene-1,2,3,5-tetracarboxylates promoted by Ph3P.2 |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 25 °C / 77 °F |
| Transport (UN / ADR) | UN 3272 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl propiolate used for?
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Ethyl propiolate is used as a building block in organic synthesis, including in asymmetric alkynylation reactions and multi-component syntheses to prepare more complex organic molecules.
What is the CAS number and formula for Ethyl propiolate?
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The CAS number for Ethyl propiolate is 623-47-2, and its formula is HC≡CCO₂C₂H₅.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl propiolate with a minimum purity of 99%. This product is intended for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should Ethyl propiolate be handled safely?
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Ethyl propiolate is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle in a well-ventilated area, wear appropriate personal protective equipment including gloves, eyeshields, and a respirator, and keep away from heat and ignition sources.
Is Ethyl propiolate packed and exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a global supplier and exporter of Ethyl propiolate, shipping to customers worldwide.
How can I request a quote or sample for Ethyl propiolate?
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To request a quote or a sample of Ethyl propiolate, please visit the product page on the Tech Serve Solutions website and use the designated inquiry form.
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