Ethyl isonipecotate
Ethyl isonipecotate (CAS: 1126-09-6; Formula: C8H15NO2; MW: 157.21) is a versatile heterocyclic building block. This piperidine derivative serves as a key reactant in the synthesis of various complex molecules. Its applications span the development of SMN protein modulators, cardiovascular disease therapeutics, and antimicrobial agents. Ethyl isonipecotate is essential for researchers and manufacturers engaged in advanced chemical synthesis and drug discovery.
- IUPAC
- Ethyl 4-piperidinecarboxylate,Piperidin-4-carboxylic acid ethyl ester
- Synonyms
- Ethyl 4-piperidinecarboxylatePiperidin-4-carboxylic acid ethyl ester
Synthesis of SMN Protein Modulators
Ethyl isonipecotate acts as a crucial reactant in the synthetic pathways for developing modulators of SMN protein, which are of interest for therapeutic applications.
Preparation of Substituted Esters
This compound is employed in rhodium-catalyzed tandem reactions for the synthesis of β-aryl and β-amino-substituted aliphatic esters.
Production of Nitroethylenediamines
It is utilized as a reactant in the nucleophilic ring-opening of nitroimidazolidinone to produce nitroethylenediamines.
Development of RhoA Inhibitors
Ethyl isonipecotate serves as a precursor in the synthesis of RhoA inhibitors, targeting cardiovascular disease therapies.
Antimicrobial and Antioxidant Agents
It is used in the preparation of saccharin-derived Mannich bases, investigated for their antimicrobial and antioxidant properties.
| Molecular weight | 157.21 |
|---|---|
| Empirical formula | C8H15NO2 |
| Assay | 98% |
| Boiling point | 204 °C(lit.) |
| Density | 1.02 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.459(lit.) |
| Application | Reactant for synthesis of:• SMN protein modulators1• β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition2• Nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone3• RhoA inhibitors for cardiovascular disease therapy4• Saccharin derived Mannich bases as antimicrobials and antioxidants5Reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates6 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 80 °C / 176 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl isonipecotate used for?
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Ethyl isonipecotate is used as a reactant in the synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters, nitroethylenediamines, RhoA inhibitors for cardiovascular disease therapy, and saccharin-derived Mannich bases with antimicrobial and antioxidant activities.
What are the CAS number and formula for Ethyl isonipecotate?
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The CAS number for Ethyl isonipecotate is 1126-09-6, and its molecular formula is C8H15NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl isonipecotate with a purity of 98%. TSS does not represent this product as USP, BP, or EP grade.
How should Ethyl isonipecotate be handled safely?
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Handling Ethyl isonipecotate requires appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. It has a flash point of 80 °C (176 °F) and is classified under WGK 2 in Germany.
Is Ethyl isonipecotate a controlled substance?
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The provided data does not indicate that Ethyl isonipecotate is a controlled substance.
How is Ethyl isonipecotate packed, shipped, and exported?
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As a specialist global supplier, Tech Serve Solutions exports fine chemicals worldwide, ensuring appropriate packaging for safe transit.
How can I request a sample or quote for Ethyl isonipecotate?
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Please contact Tech Serve Solutions directly through our website or sales representatives to request a sample or a formal quotation for Ethyl isonipecotate.
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