β-Estradiol-d2
β-Estradiol-d2 (CAS: 53866-33-4), with the chemical formula C18H22D2O2 and a molecular weight of 274.39, is a deuterated analogue of β-estradiol. This compound is primarily utilised in chemical synthesis and as a chiral building block for the construction of complex molecules. Its isotopic enrichment allows for precise tracking and quantification in various research applications, particularly in metabolic studies and as an internal standard in analytical chemistry.
- IUPAC
- 1,3,5(10)-Estratriene-2,4-d2-3,17β-diol
Internal Standard in Analytical Chemistry
The deuterated nature of β-Estradiol-d2 makes it an ideal internal standard for mass spectrometry-based assays. It allows for accurate quantification of endogenous estradiol or other related compounds in biological samples by compensating for variations in sample preparation and instrument response.
Metabolic and Pharmacokinetic Studies
Utilised in research to study the metabolism and pharmacokinetics of estradiol and its derivatives. The deuterium labelling enables researchers to trace the metabolic pathways and determine the absorption, distribution, metabolism, and excretion (ADME) profiles of oestrogenic compounds.
Isotopically Labelled Synthesis
Serves as a valuable precursor or building block in the synthesis of more complex isotopically labelled steroids. This is crucial for detailed mechanistic studies in biochemistry and medicinal chemistry.
Chiral Synthesis
As a chiral building block, it can be incorporated into the synthesis of complex chiral molecules where stereochemical integrity is paramount, contributing to asymmetric synthesis strategies.
| Molecular weight | 274.39 |
|---|---|
| Empirical formula | C18H22D2O2 |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
- H350May cause cancer
- H360May damage fertility or the unborn child
Precautionary statements
- P201Obtain special instructions before use
- P280Wear protective gloves, clothing and eye/face protection
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-46-61-20/21/22 |
| Safety statements (S) | 53-22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Isotopic Purity | 98 atom % D |
|---|---|
| Mass Shift | M+2 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is β-Estradiol-d2 primarily used for?
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β-Estradiol-d2 is primarily used as an internal standard in analytical chemistry, for metabolic and pharmacokinetic studies, and in isotopically labelled synthesis and chiral synthesis.
What are the CAS number and formula for β-Estradiol-d2?
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The CAS number for β-Estradiol-d2 is 53866-33-4, and its chemical formula is C18H22D2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies β-Estradiol-d2 with a minimum isotopic purity of 98 atom % D. We do not represent this product as USP, BP, or EP grade.
How should β-Estradiol-d2 be handled safely?
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β-Estradiol-d2 is a dangerous substance requiring specific precautions. It is harmful if swallowed, in contact with skin, or if inhaled, and is suspected of causing cancer and damaging fertility or the unborn child. Handle with appropriate personal protective equipment including eyeshields, gloves, and a suitable respirator. Always consult the safety data sheet before use.
Is β-Estradiol-d2 a controlled substance?
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Information regarding controlled substance status is not provided in the product data. Please consult your local regulations.
How is β-Estradiol-d2 packed and shipped?
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Tech Serve Solutions exports chemicals globally. Specific packaging details will be confirmed upon order, adhering to all relevant shipping regulations for hazardous materials.
How can I request a sample or quote for β-Estradiol-d2?
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To request a sample or quote, please contact our sales team through the website or by phone, providing the product name and CAS number (53866-33-4).
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