Esculin sesquihydrate
Esculin sesquihydrate (CAS: 66778-17-4), with the molecular formula C15H16O9 · 1.5H2O and a molecular weight of 367.31 g/mol, is a glycosylated coumarin derivative. It is recognised for its fluorescence properties and its role in various chemical and biological studies. This compound is valuable in research for investigating enzyme activity, plant physiology, and as a reagent in biochemical assays.
- IUPAC
- 6,7-Dihydroxycoumarin 6-glucoside,Aesculin,Aesculinum,Esculetin-6-β-D-glucopyranoside
- Synonyms
- 6,7-Dihydroxycoumarin 6-glucosideAesculinAesculinumEsculetin-6-β-D-glucopyranoside

Fluorescence Indicator
Esculin sesquihydrate exhibits fluorescence under UV light, making it useful as an indicator in various analytical and biochemical applications. Its fluorescence intensity can be modulated by environmental factors, enabling its use in probing specific conditions.
Enzyme Substrate Research
It serves as a substrate for glycosidase enzymes, particularly beta-glucosidases. Researchers utilise esculin sesquihydrate to study enzyme kinetics, identify enzyme activity, and in screening for enzyme inhibitors in biological samples.
Phytochemistry and Plant Science
Found naturally in various plant species, esculin sesquihydrate is used in phytochemistry to investigate plant secondary metabolites and their physiological roles. It can be employed in studies related to plant defence mechanisms or signalling pathways.
Chemical Synthesis Intermediate
As a carbohydrate derivative and a coumarin compound, esculin sesquihydrate can serve as a building block or intermediate in the synthesis of more complex organic molecules for pharmaceutical or materials science research.
| Molecular weight | 367.31 |
|---|---|
| Empirical formula | C15H16O9 · 1.5H2O |
| Pharmacopeia | testing conforms to Pharmacopeia |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Esculin sesquihydrate used for?
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Esculin sesquihydrate is used as a fluorescence indicator, a substrate for enzyme activity studies, in phytochemistry research, and as a potential intermediate in chemical synthesis.
What are the CAS number and molecular formula for Esculin sesquihydrate?
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The CAS number is 66778-17-4 and the molecular formula is C15H16O9 · 1.5H2O.
What grade and purity does Tech Serve Solutions supply for Esculin sesquihydrate?
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Tech Serve Solutions supplies Esculin sesquihydrate that testing conforms to Pharmacopeia. Please refer to the Certificate of Analysis for specific batch purity details. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
What are the safety and handling precautions for Esculin sesquihydrate?
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Esculin sesquihydrate is classified with a Water Hazard Class (WGK) of 3 in Germany, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area and avoid release into the environment.
How is Esculin sesquihydrate packed, shipped, and exported?
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Esculin sesquihydrate is carefully packed according to international shipping regulations for chemical substances and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for Esculin sesquihydrate?
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To request a sample or a quotation for Esculin sesquihydrate, please contact our sales department through the website or by phone.
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