Erastin
Erastin (CAS: 571203-78-6), with the molecular formula C30H31ClN4O4, is a potent inducer of apoptosis. This off-white powder is primarily utilised in cell biology research for its role in triggering programmed cell death pathways. Its specific mechanism involves the inhibition of system xc-, leading to ferroptosis. Erastin is an invaluable tool for investigating cellular stress responses and developing novel therapeutic strategies in oncology and other research areas.
- IUPAC
- 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone
Apoptosis Research
Erastin serves as a critical reagent for inducing apoptosis and ferroptosis in cellular models. It is used to study the mechanisms of programmed cell death and its implications in various physiological and pathological conditions.
Cell Biology Studies
As a bioactive small molecule, Erastin is employed to investigate cellular signaling pathways, particularly those related to oxidative stress and cell cycle regulation. Its targeted action makes it useful for dissecting complex biological processes.
Drug Discovery and Development
Researchers utilise Erastin to screen for potential therapeutic agents and to understand the molecular basis of diseases where apoptosis plays a key role. It aids in the development of novel treatments targeting cancer and other conditions.
| Molecular weight | 547.04 |
|---|---|
| Empirical formula | C30H31ClN4O4 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | off-white |
| Solubility | DMSO: >10 mg/mL |
| Storage temperature | −20°C |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... hRas(3265)mouse ... hRas(15461)rat ... hRas(293621) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Erastin used for?
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Erastin (CAS: 571203-78-6) is primarily used as a potent inducer of apoptosis and ferroptosis in cellular research. It is a valuable tool for studying programmed cell death pathways, cellular stress responses, and developing novel therapeutic strategies.
What is the CAS number and molecular formula for Erastin?
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The CAS number for Erastin is 571203-78-6, and its molecular formula is C30H31ClN4O4.
What grade and purity does Tech Serve Solutions supply for Erastin?
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Tech Serve Solutions supplies Erastin with a purity of ≥98% as determined by HPLC. This product is intended for research purposes and is not supplied as USP, BP, or EP grade.
How should Erastin be handled and stored?
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Erastin is classified as toxic if swallowed (H301) and requires careful handling. It should be stored at -20°C. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges, must be used during handling. Refer to the Safety Data Sheet for comprehensive safety information.
Is Erastin a controlled substance?
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The provided data does not indicate that Erastin is a controlled substance. However, users should always comply with local regulations regarding the procurement and use of research chemicals.
How is Erastin shipped and exported by TSS?
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Tech Serve Solutions, as a specialist global supplier and exporter, handles the packaging and shipment of Erastin in compliance with relevant regulations for hazardous materials (UN 2811 6.1 / PGIII). We ensure safe and efficient international delivery.
How can I request a quote or sample of Erastin?
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To request a quote or a sample of Erastin, please contact our sales team through the TSS website or by referencing the product's CAS number 571203-78-6.
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