(±)-DOI hydrochloride
(±)-DOI hydrochloride (CAS: 42203-78-1, C11H16INO2 · HCl) is a white to off-white solid. With a molecular weight of 357.62, this compound is primarily utilised as a research chemical, particularly in neuroscience and cell biology studies. It serves as a valuable tool for investigating receptor interactions and cellular signalling pathways, especially those involving serotonin receptors. Its applications are focused on laboratory research, contributing to a deeper understanding of biological processes.
- IUPAC
- (±)-DOI,(±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride,(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride
- Synonyms
- (±)-DOI,(±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride,(±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride

Neuroscience Research
(±)-DOI hydrochloride is a key compound for studying neurotransmission and receptor function in the brain. It is used to investigate the activity of serotonin receptors, contributing to research in areas such as mood disorders and sensory perception.
Cell Signaling Studies
This chemical serves as a pharmacological tool to probe cellular signalling pathways. Researchers utilise it to understand the complex mechanisms by which cells communicate and respond to stimuli, particularly in relation to GPCR activity.
Biochemical Research
As a biochemical reagent, (±)-DOI hydrochloride is employed in laboratory settings for various experiments. Its well-defined properties make it suitable for a range of in vitro assays aimed at understanding molecular interactions.
| Molecular weight | 357.62 |
|---|---|
| Empirical formula | C11H16INO2 · HCl |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Colour | white to off-white |
| Solubility | H2O: soluble10 mg/mLethanol: soluble2 mg/mL |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 22-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Drug Control | Home Office Schedule 1regulated under CDSA - not available from Canada |
|---|---|
| Gene Information | human ... HTR2A(3356), HTR2B(3357), HTR2C(3358) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (±)-DOI hydrochloride primarily used for?
+
(±)-DOI hydrochloride is primarily used as a research chemical in neuroscience, cell biology, and biochemical studies, particularly for investigating neurotransmission and serotonin receptor activity.
What is the CAS number and molecular formula for (±)-DOI hydrochloride?
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The CAS number is 42203-78-1, and the molecular formula is C11H16INO2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (±)-DOI hydrochloride with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling precautions for (±)-DOI hydrochloride?
+
As indicated by GHS07, (±)-DOI hydrochloride is a warning substance that can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
Is (±)-DOI hydrochloride a controlled substance?
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Yes, (±)-DOI hydrochloride is regulated under Home Office Schedule 1 and the Controlled Drugs and Substances Act (CDSA) in Canada, and is not available from Canada.
How is (±)-DOI hydrochloride shipped or exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and will handle the shipping and export of (±)-DOI hydrochloride in compliance with all relevant regulations.
How can I request a quote or sample for (±)-DOI hydrochloride?
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Please contact our sales department directly through our website or by phone to request a quote or sample for (±)-DOI hydrochloride.
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