DL-Serine hydroxamate
DL-Serine hydroxamate (CAS 55779-32-3), with the molecular formula C3H8N2O3 and a molecular weight of 120.11 g/mol, is a serine analog used in biochemical research. It functions as an inhibitor of seryl-tRNA synthetase. This compound is specifically employed to induce the metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in *E. coli* through amino acid starvation, and to synchronise cell cycle progression by inhibiting tRNA charging.
- IUPAC
- SHX
Induction of ppGpp Synthesis
DL-Serine hydroxamate serves as a tool to induce the metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in *E. coli*. This is achieved by mimicking amino acid starvation conditions, which triggers the stringent response.
Cell Cycle Synchronization
This compound is utilised to synchronise cell cycles in *E. coli* cultures. It achieves this by inhibiting the charging of tRNA molecules with amino acids, a critical step in protein synthesis and cell division.
Biochemical Research Reagent
As a serine analog that inhibits seryl-tRNA synthetase, DL-Serine hydroxamate is a valuable reagent for studies investigating aminoacyl-tRNA synthetase activity and related biological pathways.
| Molecular weight | 120.11 |
|---|---|
| Empirical formula | C3H8N2O3 |
| Storage temperature | −20°C |
| Application | Serine analog that inhibits seryl-tRNA synthetase.1,2 DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation.3 Also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging.4 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is DL-Serine hydroxamate used for?
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DL-Serine hydroxamate is used to induce the metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in *E. coli* by amino acid starvation and to synchronize cell cycle in *E. coli* cultures by inhibition of tRNA charging. It acts as a serine analog that inhibits seryl-tRNA synthetase.
What is the CAS number and chemical formula for DL-Serine hydroxamate?
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The CAS number for DL-Serine hydroxamate is 55779-32-3, and its chemical formula is C3H8N2O3.
What grade and purity does Tech Serve Solutions supply for DL-Serine hydroxamate?
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Tech Serve Solutions supplies DL-Serine hydroxamate for research purposes. The specific assay or purity is not detailed in the product data provided; therefore, TSS does not represent it as USP, BP, or EP grade.
What are the safety and handling recommendations for DL-Serine hydroxamate?
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When handling DL-Serine hydroxamate, it is essential to wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if respiratory protection is needed. The compound has a WGK Germany rating of 3, indicating a high hazard to water.
How is DL-Serine hydroxamate shipped and exported?
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DL-Serine hydroxamate is typically stored at -20°C. Tech Serve Solutions, as a global supplier and exporter of fine chemicals, handles shipping and export in compliance with relevant regulations for chemical substances.
How can I request a quote or sample for DL-Serine hydroxamate?
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To request a quote or obtain a sample of DL-Serine hydroxamate, please contact the Tech Serve Solutions sales department through our website or by phone.
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