Diphenyl phosphoryl chloride
Diphenyl phosphoryl chloride (CAS 2524-64-3) is a phosphorus halide compound with the linear formula (C₆H₅O)₂POCl and a molecular weight of 268.63 g/mol. It serves as a key intermediate in organic synthesis, particularly for the introduction of the diphenylphosphoryl group. Its reactivity makes it valuable in the preparation of various organophosphorus compounds, finding utility in research and development laboratories and fine chemical manufacturing.
- IUPAC
- Diphenyl chlorophosphate,Diphenyl phosphorochloridate
- Synonyms
- Diphenyl chlorophosphateDiphenyl phosphorochloridate

Organic Synthesis Reagent
Diphenyl phosphoryl chloride is utilized as a versatile building block in organic synthesis. It facilitates the phosphorylation of alcohols, amines, and other nucleophiles, enabling the construction of complex organophosphorus molecules.
Intermediate for Phosphorus Compounds
This compound acts as a crucial intermediate in the synthesis of a wide array of phosphorus-containing compounds. These can include flame retardants, plasticizers, and other specialty chemicals.
Research and Development
In R&D settings, diphenyl phosphoryl chloride is employed to explore novel synthetic routes and develop new chemical entities. Its predictable reactivity aids chemists in targeted molecular design.
| Molecular weight | 268.63 |
|---|---|
| Linear formula | (C6H5O)2POCl |
| Assay | 99% |
| Boiling point | 314-316 °C/272 mmHg(lit.) |
| Density | 1.296 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.55(lit.) |
| Vapour pressure | 10 mmHg (190 °C) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >113 °C / >235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diphenyl phosphoryl chloride used for?
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Diphenyl phosphoryl chloride is primarily used as a reagent in organic synthesis for the preparation of organophosphorus compounds and as a building block in chemical research and development.
What is the CAS number and formula for Diphenyl phosphoryl chloride?
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The CAS number is 2524-64-3 and the linear formula is (C₆H₅O)₂POCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diphenyl phosphoryl chloride with an assay of 99%. This product is not represented as USP, BP, or EP grade.
What are the primary safety hazards associated with Diphenyl phosphoryl chloride?
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Diphenyl phosphoryl chloride is classified as Danger, with hazard statement H314, indicating it causes severe skin burns and eye damage. Appropriate personal protective equipment, including face shields, gloves, and respirators, is essential during handling.
How is Diphenyl phosphoryl chloride packed, shipped, and exported?
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This chemical is shipped as UN 3265, Class 8, Packing Group II. Tech Serve Solutions ensures adherence to all regulations for safe global export.
How can I request a sample or quote for Diphenyl phosphoryl chloride?
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To request a sample or quote, please contact our sales team through the website or by phone, referencing the product name and CAS number.
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