Dimethyl malonate
Dimethyl malonate (CAS: 108-59-8), with the linear formula CH₂(COOCH₃)₂, has a molecular weight of 132.11 g/mol. This ester is a versatile organic building block utilised in various chemical syntheses. It is miscible with common organic solvents like alcohol, diethyl ether, and oil, though only slightly soluble in water. Tech Serve Solutions offers Dimethyl malonate as a Vetec™ reagent grade with a purity of 98%.
- Synonyms
- Malonic acid dimethyl esterMethyl malonateDimethyl ester of malonic acid
Organic Synthesis
Dimethyl malonate serves as a key intermediate in the synthesis of numerous organic compounds, including pharmaceuticals, agrochemicals, and specialty polymers. Its reactive methylene group readily participates in alkylation and condensation reactions.
Malonic Ester Synthesis
As a diester of malonic acid, it is a fundamental reagent in malonic ester synthesis. This allows for the controlled introduction of substituted malonate groups, which can then be decarboxylated to yield substituted acetic acids.
Pharmaceutical Intermediates
This compound is employed in the multi-step synthesis of various active pharmaceutical ingredients (APIs). Its structure allows for the formation of diverse heterocyclic and carbocyclic ring systems crucial in drug discovery.
Fine Chemical Production
Dimethyl malonate is a valuable component in the manufacturing of fine chemicals, contributing to the creation of complex molecules with specific functionalities for various industrial applications.
| Molecular weight | 132.11 |
|---|---|
| Linear formula | CH2(COOCH3)2 |
| Assay | 98% |
| Grade | Vetec™ reagent grade |
| Boiling point | 180-181 °C(lit.) |
| Density | 1.156 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.413(lit.) |
| Melting point | −62 °C(lit.) |
| Solubility | alcohol: misciblediethyl ether: miscibleoil: misciblewater: slightly soluble |
| Vapour density | >1 (vs air) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Flash point | 85 °C / 185 °F |
|---|---|
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dimethyl malonate used for?
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Dimethyl malonate is primarily used as a versatile building block in organic synthesis, particularly in the malonic ester synthesis pathway, for creating pharmaceuticals, agrochemicals, and fine chemicals.
What is the CAS number and chemical formula for Dimethyl malonate?
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The CAS number is 108-59-8 and the linear chemical formula is CH₂(COOCH₃)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Dimethyl malonate as Vetec™ reagent grade with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should Dimethyl malonate be handled safely?
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Dimethyl malonate is an irritant to the skin, eyes, and respiratory tract. Handle with appropriate personal protective equipment (gloves, eye protection, suitable respirator) in a well-ventilated area. Avoid breathing vapour or mist.
Is Dimethyl malonate a controlled substance?
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Dimethyl malonate is not listed as a controlled substance in major regulatory frameworks.
How is Dimethyl malonate packed, shipped, and exported?
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Dimethyl malonate is carefully packed according to international shipping regulations and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for Dimethyl malonate?
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To request a sample or a quote, please contact our sales team through the website or by phone, referencing the product name and CAS number (108-59-8).
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