Diethyl chlorophosphite
Diethyl chlorophosphite (CAS: 589-57-1) is a clear, colorless liquid with the molecular formula (C2H5O)2PCl and a molecular weight of 156.55. This versatile phosphorylating agent is crucial in organic synthesis, finding application in the esterification of enolates and the preparation of various phosphorus-containing compounds. Its reactive nature demands careful handling in accordance with its safety profile.
- IUPAC
- Diethyl chlorophosphonite,Diethyl phosphorochloridite
- Synonyms
- Diethyl phosphorochloridite
Phosphorylating Agent
Diethyl chlorophosphite serves as a key phosphorylating agent. It is effectively used for the phosphorylation of ester and lactone enolates, contributing to the synthesis of complex organic molecules.
Synthesis of Organic Intermediates
This compound is employed in the synthesis of diverse organic intermediates. Its reactivity allows for the introduction of phosphorus functionalities into various molecular structures.
Amine Phosphorylation
Diethyl chlorophosphite is utilized for the phosphorylation of amines, enabling the formation of phosphoramidites and related derivatives important in further synthetic transformations.
Preparation of Alkenols Derivatives
It finds application in the preparation of alkenols derivatives, facilitating the synthesis of specialized phosphorus-containing compounds with potential applications in materials science and catalysis.
| Molecular weight | 156.55 |
|---|---|
| Linear formula | (C2H5O)2PCl |
| Assay | 98% |
| Boiling point | 153-155 °C(lit.)56-57.5 °C/30 mmHg(lit.) |
| Density | 1.089 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.434(lit.) |
| Storage temperature | 2-8°C |
| Application | Versatile phosphorylating agent for ester and lactone enolates,1 amines,2 and alkenols.3 |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 1 °C / 33.8 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-34-37 |
| Safety statements (S) | 7/8-16-26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl chlorophosphite used for?
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Diethyl chlorophosphite is primarily used as a versatile phosphorylating agent for ester and lactone enolates, amines, and alkenols in organic synthesis.
What is the CAS number and formula for Diethyl chlorophosphite?
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The CAS number for Diethyl chlorophosphite is 589-57-1 and its linear formula is (C2H5O)2PCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl chlorophosphite with an assay of 98%. This product is not represented as USP, BP, or EP grade.
What are the main safety hazards associated with Diethyl chlorophosphite?
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Diethyl chlorophosphite is flammable (H225), causes severe skin burns and eye damage (H314), and may cause respiratory irritation (H335). It also reacts violently with water.
How is Diethyl chlorophosphite packaged and shipped?
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Diethyl chlorophosphite is shipped as UN 2924, Hazard Class 8(3), Packing Group II, and is stored at 2-8°C.
How can I request a quote or sample for Diethyl chlorophosphite?
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To request a quote or sample, please contact our sales team through the website or by phone.
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