Diethyl 1-phenylethyl phosphonate

CAS 33973-48-7C6H5(CH2)2PO(OCH2CH3)2Chemical Synthesis

Diethyl 1-phenylethyl phosphonate (CAS: 33973-48-7), with the chemical formula C6H5(CH2)2PO(OCH2CH3)2 and a molecular weight of 242.25 g/mol, is a valuable reagent in organic synthesis. It functions effectively as a reactant in various transformations, notably in C-C bond formation and olefination reactions. This compound is a key component in Horner-Wadsworth-Emmons type reactions, enabling the synthesis of complex organic molecules.

IUPAC: NSC 220102

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Diethyl 1-phenylethyl phosphonate (C6H5(CH2)2PO(OCH2CH3)2) — chemical structure, CAS 33973-48-7; Chemistry, fine chemical supplied by Tech Serve Solutions

C-C Bond FormationChemical SynthesisOlefinationSynthetic Reagents

01 /Applications

Horner-Wadsworth-Emmons Reagent

This phosphonate ester serves as a versatile reagent in Horner-Wadsworth-Emmons reactions, facilitating the formation of carbon-carbon double bonds. It is particularly useful for the olefination of aldehydes and ketones.

C-C Bond Formation

The compound is employed in synthetic strategies that require the construction of new carbon-carbon bonds. Its reactivity profile supports its use in various coupling and substitution reactions.

Carbanion Oxidative Nucleophilic Substitution

It acts as a reactant in carbanion oxidative nucleophilic substitution of hydrogen, offering a pathway for functionalisation reactions that introduce specific groups into organic structures.

02 /Properties

Molecular weight	242.25
Linear formula	C6H5(CH2)2PO(OCH2CH3)2
Assay	98%
Boiling point	130 °C/0.6 mmHg(lit.)
Density	1.082 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.496(lit.)
Application	Reactant for:• Carbanion oxidative nucleophilic substitution of hydrogen1• Base-catalyzed olefination2

03 /Safety & handling

Protective equipment	Eyeshields, Gloves
Flash point	>110 °C / >230 °F
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

33973-48-7

MDL number

MFCD00961781

PubChem substance

24878558

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Diethyl 1-phenylethyl phosphonate used for?

Diethyl 1-phenylethyl phosphonate (CAS: 33973-48-7) is used as a reactant in organic synthesis, particularly for C-C bond formation, olefination reactions, and carbanion oxidative nucleophilic substitution of hydrogen, often acting as a Horner-Wadsworth-Emmons reagent.

What is the CAS number and chemical formula for Diethyl 1-phenylethyl phosphonate?

The CAS number is 33973-48-7 and the chemical formula is C6H5(CH2)2PO(OCH2CH3)2.

What grade and purity does Tech Serve Solutions supply for Diethyl 1-phenylethyl phosphonate?

Tech Serve Solutions supplies Diethyl 1-phenylethyl phosphonate with an assay of 98%. We do not represent this product as USP, BP, or EP grade.

What are the safety considerations for handling Diethyl 1-phenylethyl phosphonate?

Appropriate personal protective equipment, including eyeshields and gloves, should be worn when handling Diethyl 1-phenylethyl phosphonate. The flash point is above 110 °C (230 °F).

How is Diethyl 1-phenylethyl phosphonate packed, shipped, and exported?

Tech Serve Solutions safely packs, ships, and exports fine chemicals globally, adhering to all relevant regulations to ensure product integrity and compliance.