Di(N-succinimidyl) glutarate
Di(N-succinimidyl) glutarate (CAS 79642-50-5), with the molecular formula C13H14N2O8 and a molecular weight of 326.26 g/mol, is a key reagent in chemical biology and synthesis. This compound functions as an active ester, readily participating in amidation reactions. It is particularly valuable as a crosslinker for creating conjugates and modifying biomolecules, facilitating the study and development of new biological tools and therapeutics.
- IUPAC
- DSG
Bioconjugation
Di(N-succinimidyl) glutarate is employed to covalently link biomolecules, such as proteins or peptides, to other molecules or surfaces. Its glutarate spacer arm allows for flexible conjugation, enabling diverse applications in diagnostics and drug delivery systems.
Peptide and Protein Modification
This reagent is used to modify amino groups on peptides and proteins, introducing a glutarate moiety. This modification can alter protein properties or serve as a handle for further chemical transformations, aiding in protein engineering and functional studies.
Surface Functionalization
Di(N-succinimidyl) glutarate can be used to functionalize surfaces with active ester groups. This enables the subsequent immobilization of biomolecules or other ligands, crucial for developing biosensors, microarrays, and affinity chromatography media.
Synthesis of Complex Molecules
In chemical synthesis, DSG serves as a bifunctional building block for constructing more complex organic molecules. Its predictable reactivity with amines makes it a reliable component in multi-step synthetic pathways.
| Molecular weight | 326.26 |
|---|---|
| Empirical formula | C13H14N2O8 |
| Assay | ≥97.0% (CHN) |
| Storage temperature | −20°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Di(N-succinimidyl) glutarate used for?
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Di(N-succinimidyl) glutarate is primarily used in chemical biology and chemical synthesis as a crosslinker and for bioconjugation. It enables the modification and linking of biomolecules like proteins and peptides, and can be used for surface functionalization.
What are the CAS number and molecular formula for Di(N-succinimidyl) glutarate?
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The CAS number is 79642-50-5 and the molecular formula is C13H14N2O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Di(N-succinimidyl) glutarate with an assay of ≥97.0% (CHN). TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should Di(N-succinimidyl) glutarate be handled safely?
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Di(N-succinimidyl) glutarate is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Ensure adequate ventilation and avoid inhaling dust.
How is Di(N-succinimidyl) glutarate stored and shipped?
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Di(N-succinimidyl) glutarate should be stored at -20°C. TSS exports chemicals globally, adhering to all relevant shipping and handling regulations for such compounds.
How can I request a sample or quote for Di(N-succinimidyl) glutarate?
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To request a sample or a quote for Di(N-succinimidyl) glutarate, please contact our sales team through the website or by calling our customer service number.
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