Crizotinib
Crizotinib (CAS: 877399-52-5), with the empirical formula C21H22Cl2FN5O and a molecular weight of 450.34 g/mol, is a potent and selective small molecule inhibitor. This compound is primarily recognised for its role as an anaplastic lymphoma kinase (ALK) and ROS1 inhibitor, making it a significant agent in targeted cancer therapies. It is supplied as a white to tan powder.
- IUPAC
- (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine,PF 2341066,PF-02341066,PF02341066,Xalkori
- Synonyms
- XalkoriPF-02341066PF2341066PF 2341066(R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
ALK and ROS1 Inhibitor
Crizotinib functions by inhibiting anaplastic lymphoma kinase (ALK) and ROS1 receptor tyrosine kinases. This mechanism is crucial for its application in treating certain types of non-small cell lung cancer (NSCLC) that harbour specific genetic alterations.
Research in Oncology
As a well-characterised bioactive small molecule, Crizotinib is used in preclinical research settings to investigate mechanisms of cancer cell signalling and explore novel therapeutic strategies against various solid tumours.
Cellular Signalling Studies
Researchers utilise Crizotinib to probe the roles of receptor tyrosine kinases, such as ALK and FGFR, in cellular processes. This aids in understanding complex signalling pathways relevant to cell biology and disease development.
| Molecular weight | 450.34 |
|---|---|
| Empirical formula | C21H22Cl2FN5O |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to tan |
| Storage temperature | room temp |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Crizotinib used for?
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Crizotinib is used as an ALK and ROS1 inhibitor, particularly in the treatment of certain types of non-small cell lung cancer (NSCLC). It is also utilised in research settings for studying cancer cell signalling and receptor tyrosine kinases.
What is the CAS number and formula for Crizotinib?
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The CAS number for Crizotinib is 877399-52-5, and its empirical formula is C21H22Cl2FN5O.
What grade and purity does Tech Serve Solutions supply for Crizotinib?
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Tech Serve Solutions supplies Crizotinib with a purity of ≥98% (HPLC). This product is intended for research purposes, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.
How should Crizotinib be handled and stored?
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Crizotinib is classified under WGK Germany 3, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area. Store at room temperature.
Is Crizotinib a controlled substance?
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The provided data does not indicate that Crizotinib is a controlled substance. However, users should always comply with local regulations regarding its procurement and use.
How is Crizotinib packed, shipped, and exported?
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Crizotinib is supplied as a powder and is available for global export by Tech Serve Solutions. Specific packing and shipping details are confirmed upon order placement.
How can I request a sample or quote for Crizotinib?
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To request a sample or a quote for Crizotinib, please contact the Tech Serve Solutions sales team through our website or via the provided contact information.
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