(−)-Corey lactone, 4-phenylbenzoate alcohol

CAS 31752-99-5C21H20O5Chemical Synthesis

(−)-Corey lactone, 4-phenylbenzoate alcohol (CAS 31752-99-5) is a chiral building block with the molecular formula C21H20O5. This lactone derivative serves as a key intermediate in the asymmetric synthesis of prostaglandins and related biologically active compounds. Its well-defined stereochemistry makes it a versatile reagent in organic synthesis, particularly for developing complex pharmaceutical agents.

IUPAC: (3aα,4α,5β,6aα)-(−)-Hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-yl 1,1′-biphenyl-4-carboxylate,(3aR,4S,5R,6aS)-Hexahydro-4-hydroxymethyl-5-(4-phenylbenzoyloxy)cyclopenta[b]furan-2-one
Synonyms: C21H20O5(3aα,4α,5β,6aα)-(−)-Hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-yl 1,1′-biphenyl-4-carboxylate(3aR,4S,5R,6aS)-Hexahydro-4-hydroxymethyl-5-(4-phenylbenzoyloxy)cyclopenta[b]furan-2-one

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(−)-Corey lactone, 4-phenylbenzoate alcohol (C21H20O5) — chemical structure, CAS 31752-99-5; Chemistry, fine chemical supplied by Tech Serve Solutions

Asymmetric SynthesisChemical SynthesisChiral Building BlocksLactonesOrganic Building Blocks

01 /Applications

Prostaglandin Synthesis

This compound is a crucial intermediate for the synthesis of various prostaglandins, which are lipid compounds with hormone-like effects involved in many physiological processes.

Antiglaucoma Agent Analogues

It acts as a building block for potent and selective analogues of PGF2α, a prostaglandin used in the treatment of glaucoma by reducing intraocular pressure.

Chiral Building Block

As a chiral molecule, it is extensively used in asymmetric synthesis to introduce specific stereochemistry into target molecules, facilitating the creation of enantiomerically pure compounds.

02 /Properties

Molecular weight	352.38
Empirical formula	C21H20O5
Assay	99%
Optical activity	[α]20/D −87°, c = 1 in chloroform
Storage temperature	2-8°C
Application	Key intermediate in the synthesis of prostaglandins.1,2 Versatile building block for prostaglandins. Building block for a potent and selective antiglaucoma agent analog of PGF2α2
Melting point	131-132 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

31752-99-5

MDL number

MFCD00078077

PubChem substance

24854983

Beilstein registry

1294692

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is (–)-Corey lactone, 4-phenylbenzoate alcohol primarily used for?

It is primarily used as a key intermediate in the synthesis of prostaglandins and as a versatile chiral building block for organic synthesis, including the development of antiglaucoma agents.

What is the CAS number and empirical formula for this compound?

The CAS number is 31752-99-5 and the empirical formula is C21H20O5.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound with an assay of 99%. We do not represent this product as USP, BP, or EP grade; it is supplied for research and chemical synthesis purposes.

What are the safety and handling requirements for this chemical?

When handling this compound, it is essential to use personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if necessary. The compound is classified under WGK 2 in Germany, indicating a hazard to water.

How is (–)-Corey lactone, 4-phenylbenzoate alcohol typically stored and shipped?

This chemical should be stored at 2-8°C. Tech Serve Solutions exports fine chemicals globally, ensuring appropriate packaging and documentation for safe international transit.

How can I request a quote or sample?

To request a quote or sample, please contact our sales department through the website or by phone, providing the product name and CAS number (31752-99-5).