cis-4-Fluoro-L-prolinamide hydrochloride
cis-4-Fluoro-L-prolinamide hydrochloride (CAS: 426844-23-7) is a fluorinated heterocyclic building block with the molecular formula C5H10ClFN2O and a molecular weight of 168.60 g/mol. This chiral compound, with an assay of 97%, is valuable in asymmetric synthesis and chemical research. Its specific stereochemistry and fluorine substitution make it a key intermediate in the development of novel pharmaceuticals and complex organic molecules. Supplied by Tech Serve Solutions, it is ideal for research and development applications.
- IUPAC
- (2S,4S)-4-Fluoropyrolidine-2-carboxamide hydrochloride

Asymmetric Synthesis
This chiral fluorinated building block serves as a crucial component in stereoselective synthesis, enabling the creation of enantiomerically pure compounds. It is instrumental in constructing complex molecules where precise stereochemical control is paramount.
Pharmaceutical Intermediate
The unique structural features of cis-4-Fluoro-L-prolinamide hydrochloride make it a valuable intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its incorporation can lead to novel drug candidates with enhanced properties.
Fluorinated Heterocycle Synthesis
This compound is employed in the development of various fluorinated heterocyclic structures. The presence of fluorine can significantly influence the pharmacokinetic and pharmacodynamic profiles of target molecules.
Chemical Research and Development
As a versatile building block, it is widely used in academic and industrial research laboratories for exploring new synthetic routes and developing novel chemical entities. It aids in the discovery of new materials and chemical processes.
| Molecular weight | 168.60 |
|---|---|
| Empirical formula | C5H10ClFN2O |
| Assay | 97% |
| Optical activity | [α]22/D −45.0°, c = 0.5 in methanol |
| Melting point | 240-245 °C |

Hazard statements
- H302Harmful if swallowed
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36-43 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is cis-4-Fluoro-L-prolinamide hydrochloride used for?
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cis-4-Fluoro-L-prolinamide hydrochloride is primarily used as a building block in asymmetric synthesis, particularly for developing novel pharmaceuticals and complex organic molecules due to its chiral and fluorinated nature.
What is the CAS number and formula for cis-4-Fluoro-L-prolinamide hydrochloride?
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The CAS number is 426844-23-7 and the empirical formula is C5H10ClFN2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies cis-4-Fluoro-L-prolinamide hydrochloride with an assay of 97%. This product is intended for research and development purposes and is not supplied as USP, BP, or EP grade.
How should cis-4-Fluoro-L-prolinamide hydrochloride be handled safely?
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cis-4-Fluoro-L-prolinamide hydrochloride is a Warning substance. It is harmful if swallowed (H302), may cause an allergic skin reaction (H317), and causes serious eye irritation (H319). Handle with appropriate personal protective equipment, including gloves, eye protection, and protective clothing, and avoid ingestion and skin/eye contact. Ensure adequate ventilation.
Is cis-4-Fluoro-L-prolinamide hydrochloride a controlled substance?
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Based on the provided data, there is no indication that cis-4-Fluoro-L-prolinamide hydrochloride is a controlled substance.
How is this chemical packed and shipped?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific packing and shipping details for cis-4-Fluoro-L-prolinamide hydrochloride are available upon request, adhering to international shipping regulations for chemical products.
How can I request a sample or quote for cis-4-Fluoro-L-prolinamide hydrochloride?
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To request a sample or a quotation for cis-4-Fluoro-L-prolinamide hydrochloride, please contact the Tech Serve Solutions sales team through our website or by phone. Our team will assist you with your inquiry.
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