Chlorambucil
Chlorambucil (CAS 305-03-3; C14H19Cl2NO2) is a nitrogen mustard alkylating agent with a molecular weight of 304.21 g/mol. It functions by irreversibly binding to DNA, which inhibits cell proliferation. Primarily known for its use in the treatment of certain cancers, it is also employed in research settings for studying cellular processes and drug development.
- IUPAC
- 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid,4-[Bis(2-chloroethyl)amino]benzenebutyric acid
- Synonyms
- 4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acid4-[Bis(2-chloroethyl)amino]benzenebutyric acid
Oncology Research
Used as a chemotherapeutic agent in the treatment of various lymphoid malignancies, including chronic lymphocytic leukaemia and non-Hodgkin lymphoma. Its mechanism involves alkylating DNA, leading to cell cycle arrest and apoptosis.
Cell Biology Studies
Applied in research to investigate DNA damage response pathways and cellular mechanisms affected by alkylating agents. It serves as a tool to probe the effects of DNA damage on cell cycle regulation and cell death.
Drug Development
Serves as a reference compound or starting material in the synthesis of novel cytotoxic agents or prodrugs. Researchers utilise its structure to design and evaluate new therapeutic strategies for cancer treatment.
| Molecular weight | 304.21 |
|---|---|
| Empirical formula | C14H19Cl2NO2 |
| Assay | ≥98.0% (T) |
| Grade | purum |
| Storage temperature | 2-8°C |
| Melting point | 65-70 °C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-25-36/37/38 |
| Safety statements (S) | 53-26-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... CYP2D6(1565) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorambucil primarily used for?
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Chlorambucil is primarily used in oncology for the treatment of certain cancers, such as chronic lymphocytic leukaemia and lymphomas, and also finds application in biological research for studying cellular mechanisms related to DNA alkylation.
What is the CAS number and chemical formula for Chlorambucil?
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The CAS number for Chlorambucil is 305-03-3, and its chemical formula is C14H19Cl2NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chlorambucil at a 'purum' grade with an assay of ≥98.0% (T). We do not represent this product as USP, BP, or EP grade.
How should Chlorambucil be handled safely?
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Chlorambucil is a dangerous substance. Handle with extreme caution, using appropriate personal protective equipment including eyeshields, face shields, gloves, and a full-face particle respirator (N100 US). Avoid inhalation, ingestion, and contact with skin and eyes. Store at 2-8°C.
Is Chlorambucil a controlled substance?
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The provided data does not indicate that Chlorambucil is a controlled substance. However, due to its hazardous nature, strict handling and regulatory compliance are advised.
How is Chlorambucil packed, shipped, and exported?
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Chlorambucil is carefully packed to ensure stability during transport. As a specialist global supplier, Tech Serve Solutions exports chemicals worldwide, adhering to all necessary international shipping regulations for hazardous materials, including UN 2811 6.1 / PGIII classification.
How can I request a sample or quote for Chlorambucil?
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To request a sample or a quote for Chlorambucil, please contact our sales department through the website or by phone, providing your specific requirements.
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