Benzyloxyacetyl chloride
Benzyloxyacetyl chloride (CAS 19810-31-2), with the linear formula C6H5CH2OCH2COCl and a molecular weight of 184.62 g/mol, is a reactive acid halide. It is employed as a crucial building block in organic synthesis. Key applications include the preparation of intermediates for fluoroquinolone antibiotics, non-racemic helicenes, and various β-lactam structures, underscoring its utility in complex molecule construction.
Fluoroquinolone Antibiotic Intermediate Synthesis
Benzyloxyacetyl chloride serves in the synthesis of intermediates like (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, a key component in creating fluoroquinolone antibiotics for treating respiratory tract infections.
Helicene Synthesis
This compound is utilised in the preparation of non-racemic helicenes, which are complex polycyclic aromatic hydrocarbons with unique chiral properties.
β-Lactam Chemistry
It acts as a precursor in the synthesis of β-lactams and substituted 2-azetidinones, enabling further elaboration into annulated β-lactam systems.
| Molecular weight | 184.62 |
|---|---|
| Linear formula | C6H5CH2OCH2COCl |
| Assay | 95% |
| Boiling point | 84-87 °C/0.4 mmHg(lit.) |
| Density | 1.17 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.523(lit.) |
| Storage temperature | 2-8°C |
| Application | Benzyloxyacetyl chloride was used in preparation of:• (S)-3-(methylamino)-3-((R)-pyrrolidin-3-yl)propanenitrile, key intermediate in the preparation of fluoroquinolone antibiotic for respiratory tract infections• non-racemic helicene• β-lactams1,2• substituted 2-azetidinones for further elaboration into annulated β-lactams |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Benzyloxyacetyl chloride used for?
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Benzyloxyacetyl chloride is primarily used as a building block in organic synthesis, notably in the preparation of intermediates for fluoroquinolone antibiotics, non-racemic helicenes, and various β-lactam structures.
What is the CAS number and formula for Benzyloxyacetyl chloride?
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The CAS number for Benzyloxyacetyl chloride is 19810-31-2, and its linear formula is C6H5CH2OCH2COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Benzyloxyacetyl chloride with an assay of 95%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Benzyloxyacetyl chloride be handled safely?
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Benzyloxyacetyl chloride is a corrosive substance that reacts violently with water. Handle with extreme care, using appropriate personal protective equipment including faceshields, gloves, goggles, and a suitable respirator. Ensure adequate ventilation and avoid contact with moisture. Refer to the Safety Data Sheet for detailed handling instructions.
How is Benzyloxyacetyl chloride shipped and exported?
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Benzyloxyacetyl chloride is shipped as UN 3265, Class 8, Packing Group II, indicating it is a corrosive solid, acidic, organic, n.o.s. Tech Serve Solutions is experienced in global export regulations for hazardous chemicals.
How can I request a quote or sample?
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To request a quote or sample of Benzyloxyacetyl chloride, please contact our sales team via the website or telephone, providing your specific requirements.
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