2-Amino-5-trifluoromethyl-1,3,4-thiadiazole
2-Amino-5-trifluoromethyl-1,3,4-thiadiazole (CAS: 10444-89-0) is a key heterocyclic building block with the molecular formula C3H2F3N3S and a molecular weight of 169.13 g/mol. This compound, identified by MDL number MFCD00003109, is primarily utilised in organic synthesis for the construction of complex molecules, particularly within the development of novel pharmaceutical intermediates and bioactive compounds.
- Synonyms
- 10444-89-0, C3H2F3N3S
Synthesis of Imidazo[2,1-b]-1,3,4-thiadiazole Derivatives
This building block serves as a precursor in the synthesis of various 2-sulfonamido/trifluoromethyl-6-(4′-substituted aryl/heteroaryl)imidazo[2,1-b]-1,3,4-thiadiazole derivatives and related bicyclic bridgehead nitrogen heterocycles.
Development of Pharmaceutical Intermediates
Its trifluoromethyl and thiadiazole functionalities make it valuable for creating complex molecular scaffolds potentially relevant in drug discovery and development programmes.
Heterocyclic Chemistry Research
2-Amino-5-trifluoromethyl-1,3,4-thiadiazole is employed in academic and industrial research for exploring new heterocyclic systems and their chemical properties.
| Molecular weight | 169.13 |
|---|---|
| Empirical formula | C3H2F3N3S |
| Assay | 97% |
| Solubility | methanol: soluble0.25 g/10 mL, clear, colorless |
| Application | 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole was used in the synthesis of:• series of 2-sulfonamido/trifluoromethyl-6-(4′-substituted aryl/heteroaryl)imidazo[2,1-b]-1,3,4-thiadiazole derivatives1• 2-trifluoromethyl/sulfonamido-5,6-diarylsubstituted imidazo[2,1-b]-1,3,4-thiadiazole derivatives1• bicyclic bridgehead itrogen heterocycles2 |
| Melting point | 225-227 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole used for?
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2-Amino-5-trifluoromethyl-1,3,4-thiadiazole is used as a building block in organic synthesis, particularly for the preparation of imidazo[2,1-b]-1,3,4-thiadiazole derivatives and other complex heterocyclic compounds relevant to pharmaceutical research.
What is the CAS number and formula for 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole?
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The CAS number is 10444-89-0 and the empirical formula is C3H2F3N3S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole with an assay of 97%. We do not represent this product as meeting USP, BP, EP, or any pharmacopoeia standards.
How should I safely handle 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole?
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This compound is a warning substance that may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (N95 US type), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust. In case of eye contact, rinse cautiously with water for several minutes (P305 + P351 + P338).
Is this chemical suitable for food or pharmaceutical use?
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This product is supplied for chemical synthesis and laboratory research purposes. It is not intended for human consumption, direct pharmaceutical use, or food applications. Its purity is specified as 97%.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. This compound is shipped and exported in compliance with international regulations for chemical transport. Please contact us for specific shipping details for your region.
How can I request a sample or quote?
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To request a sample or a quote for 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole, please use the contact form on our website or email our sales department directly, referencing the product CAS number 10444-89-0.
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