Benzo[b]thien-2-ylboronic acid
Benzo[b]thien-2-ylboronic acid (CAS 98437-23-1, C8H7BO2S, MW 178.02) is a key organometallic reagent. It serves as a versatile building block in organic synthesis, particularly for constructing complex molecules. Its utility is demonstrated in the development of pharmaceutical intermediates, including PDE4 inhibitors and CYP11B1 inhibitors for treating cortisol-dependent diseases, and in the synthesis of sensors and novel organic compounds.
- IUPAC
- 1-Benzothiophene-2-boronic acid,Benzothiophen-2-ylboronic acid,Thianaphthene-2-boronic acid
- Synonyms
- 1-Benzothiophene-2-boronic acidBenzothiophen-2-ylboronic acidThianaphthene-2-boronic acid
![Benzo[b]thien-2-ylboronic acid (C8H7BO2S) — chemical structure, CAS 98437-23-1; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F98437-23-1.png&w=3840&q=75)
Pharmaceutical Intermediate Synthesis
Used in the synthesis of PDE4 inhibitors and CYP11B1 inhibitors, which are investigated for the treatment of cortisol-dependent diseases. It acts as a crucial building block for these complex therapeutic agents.
Material Science and Sensors
Employed in the preparation of phosphorescent sensors for the quantitative detection of copper(II) ions. This application highlights its role in developing analytical tools.
Organic Synthesis Reactions
A valuable reactant in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds. Also involved in UV-promoted phenanthridine syntheses.
Biotechnology Applications
Utilised in the chemoselective modification of oncolytic adenoviruses, demonstrating its potential in advanced biotechnological research and therapeutic development.
| Molecular weight | 178.02 |
|---|---|
| Empirical formula | C8H7BO2S |
| Application | Reactant involved in:• PDE4 inhibitors1• Chemoselective modification of oncolytic adenovirus2• Synthesis of phosphorescent sensor for quantification of copper(II) ion3• UV promoted phenanthridine syntheses4• Preparation of CYP11B1 inhibitors for treatment of cortisol dependent diseases5• Suzuki-Miyaura cross-coupling reactions6 |
| Melting point | 256-260 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Benzo[b]thien-2-ylboronic acid used for?
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Benzo[b]thien-2-ylboronic acid is primarily used as a building block in organic synthesis. It is involved in the development of pharmaceutical intermediates such as PDE4 inhibitors and CYP11B1 inhibitors, in the synthesis of phosphorescent sensors for copper(II) ion detection, and in Suzuki-Miyaura cross-coupling reactions.
What are the CAS number and formula for Benzo[b]thien-2-ylboronic acid?
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The CAS number is 98437-23-1, and the empirical formula is C8H7BO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Benzo[b]thien-2-ylboronic acid typically as a technical or research grade chemical. The specific assay/purity will be detailed on the Certificate of Analysis provided with your order. We do not represent this product as USP, BP, EP, or pharmacopoeia grade unless explicitly stated.
What are the safety and handling considerations for Benzo[b]thien-2-ylboronic acid?
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Handling Benzo[b]thien-2-ylboronic acid requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if respiratory protection is needed. It has a high melting point of 256-260 °C. Refer to the Safety Data Sheet (SDS) for comprehensive hazard information.
Is Benzo[b]thien-2-ylboronic acid a controlled substance?
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The provided data does not indicate that Benzo[b]thien-2-ylboronic acid (CAS 98437-23-1) is a controlled substance.
How is Benzo[b]thien-2-ylboronic acid packed, shipped, and exported?
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Tech Serve Solutions packs and exports chemicals in compliance with international shipping regulations. Packaging is designed to maintain product integrity and safety during transit. Please contact us for specific export documentation and shipping inquiries.
How can I request a sample or a quote for Benzo[b]thien-2-ylboronic acid?
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To request a sample or a quote, please visit the 'Contact Us' section of the Tech Serve Solutions website or contact our sales department directly. Please specify the product name and CAS number (98437-23-1) in your request.
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