ATPO

CAS 252930-37-3C11H19N2O7PCell Biology

ATPO (CAS 252930-37-3), with the molecular formula C11H19N2O7P and a molecular weight of 322.25 g/mol, is a phosphono amino acid. It functions as a competitive antagonist at GluR1-4 (AMPA-preferring) receptors. ATPO is structurally a hybrid of NMDA and AMPA/GluR5 receptor ligands. It is utilised in neuroscience research for its specific interactions with ionotropic glutamate receptors.

IUPAC: (R,S)-2-Amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

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ATPO (C11H19N2O7P) — chemical structure, CAS 252930-37-3; Life Science, fine chemical supplied by Tech Serve Solutions

AMPA/Kainate AntagonistsAN-AZBioactive Small MoleculesCell BiologyExcitatory Amino AcidsIon ChannelsLigand-Gated Ion ChannelsNeuroscienceNeurotransmissionNeurotransmitters More...

01 /Applications

Neuroscience Research

ATPO serves as a valuable tool in neuroscience, specifically for studying the roles of AMPA-preferring receptors in neuronal signalling and function. Its antagonist properties allow researchers to investigate receptor subtypes and their involvement in synaptic transmission.

Ligand-Gated Ion Channel Studies

As a modulator of ionotropic glutamate receptors, ATPO is employed to probe the mechanisms of ligand-gated ion channels. This helps in understanding the complex pathways of neurotransmission and excitatory amino acid signalling.

Cell Signaling Investigations

The compound aids in the investigation of cell signaling pathways, particularly those influenced by excitatory amino acids. Its selective antagonism provides insights into cellular responses mediated by AMPA receptors.

02 /Properties

Molecular weight	322.25
Empirical formula	C11H19N2O7P
Form	solid
Solubility	1 M NaOH: soluble7 mg/mLDMSO: insolubleH2O: insoluble
Application	The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO) is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors. ATPO is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA/GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA).

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

252930-37-3

MDL number

MFCD03452828

PubChem substance

24278239

05 /Additional specifications

Gene Information	human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)rat ... Gria1(50592), Grik1(29559), Grin2a(24409)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is ATPO used for?

ATPO is primarily used in neuroscience research as a competitive antagonist at GluR1-4 (AMPA-preferring) receptors, aiding the study of neuronal signalling, neurotransmission, and excitatory amino acid pathways.

What are the CAS number and formula for ATPO?

The CAS number for ATPO is 252930-37-3, and its empirical formula is C11H19N2O7P.

What grade and purity does Tech Serve Solutions supply for ATPO?

Tech Serve Solutions supplies ATPO as a research-grade chemical. The assay and purity information is detailed on the product's Certificate of Analysis. TSS does not represent this product as USP, BP, EP, or for pharmaceutical, nutraceutical, or food use.

What are the safety and handling recommendations for ATPO?

ATPO is classified with WGK Germany 3. Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter, should be used. Refer to the Safety Data Sheet for comprehensive handling information.

How is ATPO typically packed and shipped?

ATPO is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions in compliance with all relevant shipping regulations.

How can I request a quote or sample for ATPO?

To request a quote or a sample of ATPO, please use the 'Request a Quote' or 'Request a Sample' buttons on the product page or contact our sales team directly.