Atovaquone

CAS 95233-18-4C22H19ClO3Cell Biology

Atovaquone (CAS: 95233-18-4, C22H19ClO3) is a potent inhibitor of the cytochrome bc1 complex. This naphthoquinone derivative exhibits significant antimalarial activity and is used in the treatment and prophylaxis of Pneumocystis jirovecii pneumonia (PCP), particularly in immunocompromised individuals. Its mechanism involves disrupting mitochondrial electron transport, vital for parasitic and fungal survival. Available from Tech Serve Solutions as a high-purity research chemical.

IUPAC: Mepron,trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
Synonyms: Meprontrans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione

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Atovaquone (C22H19ClO3) — chemical structure, CAS 95233-18-4; Life Science, fine chemical supplied by Tech Serve Solutions

AN-AZBioactive Small MoleculesCell BiologyGlaxoSmithKlineImmune System Regulation

01 /Applications

Treatment of Toxoplasmosis

Atovaquone is employed in the treatment of toxoplasmosis, an infection caused by the parasite *Toxoplasma gondii*. It targets the parasite's mitochondrial function to inhibit its growth and replication.

Prophylaxis and Treatment of Pneumocystis Pneumonia (PCP)

It is a key therapeutic agent for preventing and treating Pneumocystis pneumonia, especially in patients with compromised immune systems, such as those with HIV/AIDS or post-transplant recipients. Atovaquone disrupts the respiratory chain in *Pneumocystis jirovecii*.

Antimalarial Agent

Possessing antimalarial properties, atovaquone interferes with essential metabolic pathways in *Plasmodium* species, making it a valuable component in malaria treatment regimens.

02 /Properties

Empirical formula	C22H19ClO3
Assay	≥98% (HPLC)
Form	powder
Colour	yellow
Solubility	DMSO: >10 mg/mL
Storage temperature	−20°C
Application	Atovaquone inhibits the cytochrome bc(1) complex via interactions with the Rieske iron-sulfur protein and cytochrome b in the ubiquinol oxidation pocket. In addition to its use as a treatment for toxoplasmosis, atovaquone has antimalarial properties and prevents pneumocystis pneumonia post-renal transplant.

03 /Safety & handling

Water hazard class (WGK, DE)	3
Hazard codes (EU)	N
Risk statements (R)	50/53
Safety statements (S)	60-61

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

95233-18-4

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Atovaquone used for?

Atovaquone is primarily used for the treatment and prophylaxis of Pneumocystis pneumonia (PCP) and toxoplasmosis, and it also exhibits antimalarial properties.

What are the CAS number and formula for Atovaquone?

The CAS number for Atovaquone is 95233-18-4, and its empirical formula is C22H19ClO3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Atovaquone with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should Atovaquone be handled and stored?

Atovaquone is classified as toxic to aquatic life with long-lasting effects (50/53). It should be stored at -20°C. Handle with appropriate personal protective equipment to avoid exposure, and prevent release into the environment.

How is Atovaquone packed, shipped, and exported?

Atovaquone is carefully packed for secure transport and is available for global export by Tech Serve Solutions, adhering to international shipping regulations for chemical compounds.