Amlodipine besylate
Amlodipine besylate (CAS: 111470-99-6), with the empirical formula C20H25ClN2O5 · C6H5SO3H and a molecular weight of 567.05 g/mol, is a white powder. This L-type calcium channel blocker is primarily used in the treatment of angina pectoris and hypertension. Its biological activity also extends to inhibiting human epidermoid carcinoma A431 cell growth and demonstrating antireproductive effects in male rats.
- IUPAC
- 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate,Norvasc
- Synonyms
- 2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate, Norvasc
Treatment of Hypertension
Amlodipine besylate functions as an L-type calcium channel blocker, making it effective in managing high blood pressure. It works by relaxing blood vessels, thereby lowering blood pressure.
Management of Angina Pectoris
This compound is utilised for the therapeutic management of angina pectoris, a condition characterised by chest pain due to insufficient blood supply to the heart muscle.
Research and Development
Amlodipine besylate serves as a valuable tool in pharmacological research, particularly in studies involving calcium channels, cell signaling, and the development of new cardiovascular therapies. Its effects on cell growth also make it a subject of interest in cancer research.
| Molecular weight | 567.05 |
|---|---|
| Empirical formula | C20H25ClN2O5 · C6H5SO3H |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white |
| Solubility | DMSO: ≥20 mg/mL |
| Application | Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Amlodipine besylate used for?
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Amlodipine besylate is used for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain). It is also utilised in research settings for its effects on calcium channels, cell growth, and reproductive systems.
What are the CAS number and formula for Amlodipine besylate?
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The CAS number for Amlodipine besylate is 111470-99-6, and its empirical formula is C20H25ClN2O5 · C6H5SO3H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Amlodipine besylate with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
How should Amlodipine besylate be handled safely?
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Amlodipine besylate is classified as a Warning. It is harmful if swallowed and causes skin and eye irritation, and may cause respiratory irritation (H302-H315-H319-H335). Appropriate personal protective equipment including a dust mask (N95 US), eyeshields, face shields, and gloves should be used. Handle in a well-ventilated area.
Is Amlodipine besylate a controlled substance?
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The provided data does not indicate that Amlodipine besylate is a controlled substance.
How is Amlodipine besylate packed, shipped, and exported?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals. Products are carefully packed according to international shipping regulations to ensure safe transit and are available for export worldwide.
How can I request a sample or quote for Amlodipine besylate?
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To request a sample or a quotation for Amlodipine besylate, please contact our sales team through the website or direct inquiry channels.
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