N,N-Dimethylisobutyramide
N,N-Dimethylisobutyramide (CAS 21678-37-5) is an organic compound with the molecular formula (CH3)2CHCON(CH3)2 and a molecular weight of 115.17 g/mol. This amide is characterised by its isobutyryl group attached to a dimethylamino moiety. It serves as a valuable building block and intermediate in various chemical synthesis applications, particularly within organic chemistry research and development.
- IUPAC
- N,N,2-Trimethylpropionamide
- Synonyms
- (CH3)2CHCON(CH3)2N,N,2-Trimethylpropionamide

Organic Synthesis Intermediate
N,N-Dimethylisobutyramide is utilised as a versatile intermediate in the synthesis of more complex organic molecules. Its structure allows for various chemical transformations, making it a useful component in multi-step synthetic routes.
Research and Development
This compound finds application in laboratory settings for research purposes, enabling chemists to explore new reaction pathways and develop novel chemical entities. Its role as a building block supports the creation of diverse molecular architectures.
Fine Chemical Production
As a fine chemical, N,N-Dimethylisobutyramide can be employed in the production of specialised chemicals. Its specific functional groups make it suitable for incorporation into targeted molecular designs.
| Molecular weight | 115.17 |
|---|---|
| Linear formula | (CH3)2CHCON(CH3)2 |
| Assay | 99% |
| Boiling point | 175-176 °C/744 mmHg(lit.) |
| Density | 0.892 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.439(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 154 °C / 309.2 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N-Dimethylisobutyramide used for?
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N,N-Dimethylisobutyramide is used as an intermediate and building block in organic synthesis and for research and development purposes.
What is the CAS number and chemical formula for N,N-Dimethylisobutyramide?
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The CAS number is 21678-37-5 and the linear formula is (CH3)2CHCON(CH3)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N-Dimethylisobutyramide with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should N,N-Dimethylisobutyramide be handled?
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N,N-Dimethylisobutyramide is a Warning substance that can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure adequate ventilation.
Is N,N-Dimethylisobutyramide a controlled substance?
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The provided data does not indicate that N,N-Dimethylisobutyramide is a controlled substance.
How are your chemicals packed and shipped?
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N,N-Dimethylisobutyramide is packed in accordance with industry standards for safe transport. We export globally, adhering to all relevant shipping regulations.
How can I request a sample or quote for N,N-Dimethylisobutyramide?
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To request a sample or quote, please contact our sales team through the TSS website or by phone.
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