Allyl tetraisopropylphosphorodiamidite
Allyl tetraisopropylphosphorodiamidite (CAS 108554-72-9) is a chemical compound with the linear formula [[(CH3)2CH]2N]2POCH2CH=CH2 and a molecular weight of 288.41 g/mol. This phosphitylation agent is primarily utilised in the synthesis of oligonucleotides. Its selective deallylation can be achieved through palladium catalysis, making it a valuable reagent in nucleoside chemistry and broader chemical synthesis.
![Allyl tetraisopropylphosphorodiamidite ([[(CH3)2CH]2N]2POCH2CH=CH2) — chemical structure, CAS 108554-72-9; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F108554-72-9.png&w=3840&q=75)
Oligonucleotide Synthesis
Allyl tetraisopropylphosphorodiamidite serves as a key phosphitylation agent in the preparation of oligonucleotides. Its structure allows for controlled incorporation during the synthesis of DNA and RNA strands.
Chemical Synthesis
This compound is a useful building block in general chemical synthesis. The presence of the allyl group allows for selective removal under specific conditions, such as palladium catalysis, enabling complex molecular construction.
Nucleoside Chemistry
Within nucleoside chemistry, it functions as a reagent for modifying or preparing nucleoside derivatives. The phosphitylation capability is critical for linking nucleotide units.
Coupling Reagents
As a coupling reagent, it facilitates the formation of phosphodiester bonds, which are fundamental to the structure of nucleic acids. Its specific reactivity profile is advantageous in this context.
| Molecular weight | 288.41 |
|---|---|
| Linear formula | [[(CH3)2CH]2N]2POCH2CH=CH2 |
| Assay | 95% |
| Boiling point | 114-117 °C/0.4 mmHg(lit.) |
| Density | 0.903 g/mL at 25 °C(lit.)0.910 g/mL at 25 °C |
| Refractive index | n20/D 1.466(lit.)n20/D 1.467 |
| Storage temperature | 2-8°C |
| Application | Phosphitylation agent used in the preparation of oligonucleotides. Selective deallylation is accomplished by palladium catalysis. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Flash point | 86 °C / 186.8 °F |
|---|---|
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Allyl tetraisopropylphosphorodiamidite used for?
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Allyl tetraisopropylphosphorodiamidite is primarily used as a phosphitylation agent in the preparation of oligonucleotides and in general chemical synthesis, particularly within nucleoside chemistry.
What are the CAS number and formula for Allyl tetraisopropylphosphorodiamidite?
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The CAS number for Allyl tetraisopropylphosphorodiamidite is 108554-72-9. Its linear formula is [[(CH3)2CH]2N]2POCH2CH=CH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Allyl tetraisopropylphosphorodiamidite with a minimum assay of 95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Allyl tetraisopropylphosphorodiamidite be handled safely?
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Allyl tetraisopropylphosphorodiamidite is classified as a Warning substance (GHS07) and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle in a well-ventilated area, wear appropriate protective gloves, eye protection, and face protection. Avoid breathing dust/fume/gas/mist/vapours/spray. In case of contact with eyes, rinse cautiously with water for several minutes and seek medical advice if irritation persists.
How is Allyl tetraisopropylphosphorodiamidite typically shipped and exported?
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Allyl tetraisopropylphosphorodiamidite is shipped and exported according to its chemical classification and hazard profile, adhering to international transport regulations. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or a sample of Allyl tetraisopropylphosphorodiamidite, please contact our sales department through the website or by phone, providing your details and the quantity required.
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