AICAR
AICAR (CAS 2627-69-2), a bio-active molecule with the formula C9H14N4O5 and a molecular weight of 258.23 g/mol, is supplied by Tech Serve Solutions as a tan powder. It serves as a crucial research tool in various biological studies, particularly in understanding cellular energy metabolism and signaling pathways. AICAR is recognized for its role in activating AMP-activated protein kinase (AMPK), influencing processes like glucose uptake and fatty acid oxidation. Its applications span cancer research, cell biology, and metabolic studies.
- IUPAC
- 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside,Acadesine,N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
- Synonyms
- 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranosideAcadesineN1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide
AMPK Pathway Research
AICAR is widely used as an activator of AMP-activated protein kinase (AMPK). This makes it invaluable for studying cellular energy homeostasis, glucose metabolism, and fatty acid oxidation in various research settings.
Cancer Metabolism Studies
Given its influence on aerobic glycolysis (the Warburg Effect), AICAR is employed in research investigating cancer cell metabolism. It helps scientists understand how cancer cells utilize glucose differently and explore potential therapeutic targets.
Cellular Signaling Investigations
As a bioactive small molecule, AICAR aids in the exploration of complex cellular signaling cascades. Its effects on pathways related to cell growth, survival, and energy production are key areas of study.
Metabolic Syndrome Research
Researchers utilize AICAR to investigate mechanisms underlying metabolic disorders. Its impact on glucose uptake and energy expenditure makes it a relevant tool for studying conditions like diabetes and obesity.
| Molecular weight | 258.23 |
|---|---|
| Empirical formula | C9H14N4O5 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | tan |
| Solubility | H2O: >7 mg/mL |
| Storage temperature | −20°C |
| Melting point | 214-215 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | dry ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is AICAR used for?
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AICAR is primarily used in research as an activator of AMP-activated protein kinase (AMPK), a key regulator of cellular energy metabolism. It is also studied for its effects on aerobic glycolysis, cancer metabolism, and various cell signaling pathways.
What is the CAS number and formula for AICAR?
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AICAR has the CAS number 2627-69-2 and the empirical formula C9H14N4O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies AICAR with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should AICAR be handled safely?
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AICAR is a warning substance that may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). When handling, use a dust mask type N95 (US), eyeshields, and gloves. Ensure good ventilation and avoid dust formation. Store at -20°C.
How is AICAR packed and shipped?
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AICAR is supplied as a tan powder and shipped in dry ice to maintain its stability during transit.
How can I request a sample or quote for AICAR?
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To request a sample or obtain a quote for AICAR, please contact our sales team through the website or by phone, referencing the product name and CAS number 2627-69-2.
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