Acetyltrimethylsilane
Acetyltrimethylsilane (CAS: 13411-48-8), with the linear formula (CH3)3SiCOCH3, is an organosilicon compound with a molecular weight of 116.23 g/mol. It functions as a valuable reagent in organic synthesis, particularly in organometallic chemistry. This compound is utilised for introducing the trimethylsilylacetyl group and in various functional group transformations.
- IUPAC
- 1-(Trimethylsilyl)ethanone
- Synonyms
- 1-(Trimethylsilyl)ethanone

Organic Synthesis Reagent
Acetyltrimethylsilane serves as a versatile reagent in organic synthesis. It is employed in reactions requiring the introduction of the trimethylsilylacetyl moiety or for specific functional group manipulations.
Organosilicon Chemistry
As an organosilicon compound, it finds application in studies and syntheses within organosilicon chemistry. Its structure allows for unique reactivity patterns characteristic of silicon-containing molecules.
Intermediate in Chemical Manufacturing
This compound can act as an intermediate in the multi-step synthesis of more complex organic molecules, contributing to the development of novel chemical entities.
| Molecular weight | 116.23 |
|---|---|
| Linear formula | (CH3)3SiCOCH3 |
| Assay | 97% |
| Density | 0.811 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.411(lit.) |
| Storage temperature | 2-8°C |


Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 8 °C / 46.4 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Acetyltrimethylsilane used for?
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Acetyltrimethylsilane is primarily used as a reagent in organic synthesis, particularly for introducing the trimethylsilylacetyl group and in various transformations within organometallic and organosilicon chemistry.
What is the CAS number and formula for Acetyltrimethylsilane?
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The CAS number for Acetyltrimethylsilane is 13411-48-8, and its linear formula is (CH3)3SiCOCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Acetyltrimethylsilane with an assay of 97%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should Acetyltrimethylsilane be handled safely?
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Acetyltrimethylsilane is a flammable liquid and vapour (H225) and can cause skin (H315), serious eye (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, in a well-ventilated area, away from ignition sources.
Is Acetyltrimethylsilane shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals and can arrange for the shipment of Acetyltrimethylsilane worldwide.
How can I request a sample or quote for Acetyltrimethylsilane?
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To request a sample or obtain a quote for Acetyltrimethylsilane, please contact our sales department via the website or email.
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