8-Quinolinesulfonyl chloride
8-Quinolinesulfonyl chloride (CAS: 18704-37-5) is a key heterocyclic building block with the molecular formula C9H6ClNO2S and a molecular weight of 227.67 g/mol. This compound functions as a valuable reagent in chemical synthesis, particularly noted for its utility in oligonucleotide and olefin synthesis. Supplied by Tech Serve Solutions, it is characterised by its reactivity and specific applications in advanced organic chemistry research and development.

Oligonucleotide Synthesis
8-Quinolinesulfonyl chloride serves as an effective coupling reagent in the synthesis of oligonucleotides, facilitating the formation of phosphodiester bonds critical for genetic material construction.
Olefin Synthesis
This compound is employed in the synthesis of olefins from secondary esters under moderate temperature conditions, offering a specific pathway for alkene formation in organic chemistry.
Chemical Synthesis Reagent
As a versatile building block, 8-Quinolinesulfonyl chloride finds application in diverse chemical synthesis pathways, contributing to the construction of complex organic molecules.
| Molecular weight | 227.67 |
|---|---|
| Empirical formula | C9H6ClNO2S |
| Assay | ≥96.0% (AT) |
| Solubility | methanol: soluble10 mg/mL, clear, colorless to light yellow |
| Application | 8-Quinolinesulfonyl chloride was used as a coupling reagent in oligonucleotide synthesis1,2,3. It was also used in the synthesis of olefins from secondary esters at moderate temperature4 |
| Melting point | 126-129 °C(lit.)126-129 °C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 8-Quinolinesulfonyl chloride primarily used for?
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8-Quinolinesulfonyl chloride is primarily used as a coupling reagent in oligonucleotide synthesis and in the synthesis of olefins from secondary esters.
What are the CAS number and molecular formula for 8-Quinolinesulfonyl chloride?
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The CAS number for 8-Quinolinesulfonyl chloride is 18704-37-5, and its molecular formula is C9H6ClNO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 8-Quinolinesulfonyl chloride with an assay of ≥96.0% (AT). This is a technical/research grade product, and we do not represent it as USP, BP, or EP grade.
How should 8-Quinolinesulfonyl chloride be handled safely?
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8-Quinolinesulfonyl chloride is classified as Danger and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator, must be worn during handling. Always consult the Safety Data Sheet for detailed safety and handling procedures.
Is 8-Quinolinesulfonyl chloride available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 8-Quinolinesulfonyl chloride.
How can I request a quote or sample for 8-Quinolinesulfonyl chloride?
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To request a quote or sample for 8-Quinolinesulfonyl chloride, please contact our sales team through the website or by phone.
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