7-Methoxycoumarin-4-acetyl-Pro-Leu-Gly-Leu-β-(2,4-dinitrophenylamino)Ala-Arg amide
7-Methoxycoumarin-4-acetyl-Pro-Leu-Gly-Leu-β-(2,4-dinitrophenylamino)Ala-Arg amide (CAS: 140430-53-1) is a highly specific, internally quenched substrate designed for the assay of matrix metalloproteinases (MMPs). Upon enzymatic cleavage by MMPs, it yields the fluorescent product 7-methoxycoumarin-4-acetic acid (Mca). This peptide is crucial for biochemical and cell biology research, particularly in studies involving cell signaling, neuroscience, and the extracellular matrix.
- IUPAC
- 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide
- Synonyms
- 7-Methoxycoumarin-4-acetyl-Pro-Leu-Gly-Leu-β-(2,4-dinitrophenylamino)Ala-Arg amide
Matrix Metalloproteinase (MMP) Assays
Serves as an internally quenched substrate for the detection and quantification of matrix metalloproteinase activity. Enzymatic cleavage releases a fluorescent product, enabling sensitive detection.
Protease Activity Profiling
Useful for profiling protease activity in biological samples, particularly those related to extracellular matrix degradation and cell signaling pathways.
Cell Biology Research
Applied in cell biology studies to investigate processes involving enzymes that degrade extracellular matrix components or participate in cell signaling cascades.
Neuroscience Research
Relevant in neuroscience research for studying MMP involvement in neuronal function, plasticity, and neurological disorders.
| Molecular weight | 1093.15 |
|---|---|
| Empirical formula | C49H68N14O15 |
| Assay | ≥97% (HPLC) |
| Storage temperature | −20°C |
| Application | Internally quenched substrate for the assay of matrix metalloproteinases; yields fluorescent product MOCAc-Pro-Leu-Gly. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 7-Methoxycoumarin-4-acetyl-Pro-Leu-Gly-Leu-β-(2,4-dinitrophenylamino)Ala-Arg amide used for?
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This compound is an internally quenched substrate used for the assay of matrix metalloproteinases (MMPs), yielding a fluorescent product upon cleavage.
What is the CAS number and formula for this compound?
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The CAS number is 140430-53-1, and the empirical formula (Hill notation) is C49H68N14O15.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥97% (HPLC). It is supplied for research purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling recommendations?
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When handling, it is recommended to use safety measures such as eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is advised. This compound has a WGK classification of 3 in Germany.
How is this product shipped and exported?
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This product is typically shipped and exported under conditions suitable for preserving its integrity, requiring storage at -20°C.
How can I request a sample or quote?
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To request a sample or quote, please contact our customer service team through the website or by phone. Specify the product name and CAS number.
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