7-Aminoindole
7-Aminoindole (CAS 5192-04-1) is a fine chemical compound with the molecular formula C8H8N2 and a molecular weight of 132.16 g/mol. This indole derivative serves as a valuable building block in organic synthesis. Its primary applications lie in the development of advanced molecules, including fluorescent sensors, enzyme inhibitors targeting kinases and proteases, and antagonists for various biological receptors.
- IUPAC
- (Indol-7-yl)amine,7-Indolylamine
Fluorescent Anion Receptors and Sensors
7-Aminoindole is a key reactant in the synthesis of novel fluorescent probes. These probes are designed for the detection and quantification of specific anions in various chemical and biological systems.
Enzyme Inhibitors
The compound is utilised in the preparation of potent inhibitors for enzymes such as Protein Kinase C θ (PKCθ), Factor Xa, and Aurora kinase. It also plays a role in developing histone deacetylase (HDAC) inhibitors.
Receptor Antagonists
7-Aminoindole is employed in the synthesis of antagonists for biological receptors, notably the Mineralocorticoid Receptor and TRPV1. These molecules are investigated for their therapeutic potential.
Chemical Synthesis Intermediate
As a versatile heterocyclic building block, 7-Aminoindole is integral to complex multi-step syntheses within the fine chemical and pharmaceutical industries.
| Molecular weight | 132.16 |
|---|---|
| Empirical formula | C8H8N2 |
| Assay | ≥95.0% (HPLC) |
| Application | Reactant for preparation of:• Fluorescent anion receptors and sensors1,2• Sulfate receptors3• Protein Kinase C θ (PKCθ) inhibitors4• Factor Xa Inhibitors5• Aurora kinase inhibitor• Antagonist of Mineralocorticoid Receptor6• Potent histone deacetylase (HDAC) inhibitors7• TRPV1 antagonists8• Derivatives of N-(7-indolyl)benzenesulfonamide as cell cycle inhibitors9 |
| Melting point | 96-100 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 7-Aminoindole used for?
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7-Aminoindole is primarily used as a building block in chemical synthesis. It is a key reactant in the preparation of fluorescent anion receptors and sensors, sulfate receptors, various enzyme inhibitors (e.g., Protein Kinase C θ, Factor Xa, Aurora kinase, histone deacetylase), and receptor antagonists (e.g., Mineralocorticoid Receptor, TRPV1).
What are the CAS number and molecular formula for 7-Aminoindole?
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The CAS number for 7-Aminoindole is 5192-04-1, and its molecular formula is C8H8N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 7-Aminoindole with a purity of ≥95.0% (HPLC). TSS does not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should 7-Aminoindole be handled safely?
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7-Aminoindole is classified as a warning substance with hazards H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Ensure adequate ventilation, avoid breathing dust, and wear protective clothing.
Is 7-Aminoindole available for export and how is it shipped?
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Yes, 7-Aminoindole is available for global export by Tech Serve Solutions. It is packaged and shipped in accordance with international regulations for chemical transport.
How can I request a sample or quote for 7-Aminoindole?
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To request a sample or a quotation for 7-Aminoindole, please contact our sales team via the website or direct email, providing your specific requirements and delivery details.
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