7-Allyl-7,8-dihydro-8-oxoguanosine
7-Allyl-7,8-dihydro-8-oxoguanosine (CAS 121288-39-9) is a nucleoside derivative with the molecular formula C13H17N5O6. This compound is recognised for its role in chemical biology and nucleoside chemistry, particularly as a selective toll-like receptor 7 (TLR7) agonist. It activates immune cells, leading to increased cytokine production, making it a valuable tool in immunological research and potentially in the development of immunomodulatory agents.
- IUPAC
- Loxoribine
- Synonyms
- C13H17N5O6Loxoribine
Immune System Modulation
As a selective toll-like receptor 7 (TLR7) agonist, 7-Allyl-7,8-dihydro-8-oxoguanosine activates immune cells. This activation stimulates the production of cytokines, crucial signalling molecules in the immune response.
Chemical Biology Research
This compound serves as a valuable research tool in chemical biology. Its specific interaction with TLR7 allows for the study of innate immune pathways and the development of agonists for therapeutic applications.
Nucleoside Chemistry
Within nucleoside chemistry, 7-Allyl-7,8-dihydro-8-oxoguanosine is significant for its structural characteristics and biological activity. It aids in the exploration of modified nucleosides and their potential functions.
Chemical Synthesis
The compound is utilised in chemical synthesis as a building block or intermediate. Its unique structure can be incorporated into more complex molecules for various research purposes.
| Molecular weight | 339.30 |
|---|---|
| Empirical formula | C13H17N5O6 |
| Assay | 95% |
| Optical activity | [α]21/D −32°, c = 1 in H2O |
| Application | Loxoribine is a selective toll-like receptor 7 (TLR7) agonist that activates immune cells and increases cytokine production. |
| Melting point | 227-230 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 7-Allyl-7,8-dihydro-8-oxoguanosine used for?
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7-Allyl-7,8-dihydro-8-oxoguanosine is used as a selective toll-like receptor 7 (TLR7) agonist to activate immune cells and increase cytokine production. It is applied in chemical biology, chemical synthesis, and nucleoside chemistry research.
What is the CAS number and molecular formula for 7-Allyl-7,8-dihydro-8-oxoguanosine?
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The CAS number for 7-Allyl-7,8-dihydro-8-oxoguanosine is 121288-39-9. Its empirical formula (Hill notation) is C13H17N5O6, and its molecular weight is 339.30 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 7-Allyl-7,8-dihydro-8-oxoguanosine with a minimum assay of 95%. This product is intended for research and laboratory use. Tech Serve Solutions does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for 7-Allyl-7,8-dihydro-8-oxoguanosine?
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When handling 7-Allyl-7,8-dihydro-8-oxoguanosine, it is essential to use personal protective equipment including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if necessary. The compound has a GHS classification indicating it is hazardous. It is considered combustible, and care should be taken to avoid ignition sources.
How is 7-Allyl-7,8-dihydro-8-oxoguanosine packed, shipped, and exported?
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Tech Serve Solutions carefully packs and ships chemicals in compliance with all relevant international regulations for hazardous materials. We offer global export services for research and industrial clients.
How can I request a sample or quote for 7-Allyl-7,8-dihydro-8-oxoguanosine?
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To request a sample or a quotation for 7-Allyl-7,8-dihydro-8-oxoguanosine, please contact our sales team through the website or by calling our customer service line. Please reference the product name and CAS number.
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