6-Nitroso-1,2-benzopyrone
6-Nitroso-1,2-benzopyrone (CAS 130506-22-8), with the molecular formula C9H5NO3 and a molecular weight of 175.14 g/mol, is a chemical compound primarily recognised for its role as an inhibitor of ADP-ribosyltransferase enzymes. It functions by binding to the DNA-recognizing domain of these enzymes, selectively destabilising polypeptide complexes and significantly reducing enzyme activity while maintaining DNA binding. This makes it a valuable reagent in biochemical research.
- Synonyms
- C9H5NO3
ADP-ribosyltransferase Inhibition
6-Nitroso-1,2-benzopyrone acts as a potent inhibitor for ADP-ribosyltransferase enzymes. It specifically targets the DNA-recognizing domain, leading to the destabilisation of zinc finger polypeptide complexes and a marked decrease in enzymatic activity.
Biochemical Research Reagent
Due to its specific inhibitory action on ADP-ribosyltransferases, this compound is a useful tool in biochemical and molecular biology research. It aids in studying enzyme mechanisms, DNA-protein interactions, and cellular signalling pathways regulated by these enzymes.
Enzyme Mechanism Studies
Researchers can utilise 6-Nitroso-1,2-benzopyrone to investigate the finer details of ADP-ribosyltransferase function. Its ability to inhibit the enzyme while still allowing DNA binding provides insights into the catalytic and structural aspects of the enzyme-DNA complex.
| Molecular weight | 175.14 |
|---|---|
| Empirical formula | C9H5NO3 |
| Storage temperature | −20°C |
| Application | Binds to the DNA-recognizing domain of ADP-ribosyltransferase and preferentially destabilizes one of the two zinc finger polypeptide complexes. The affected enzyme loses almost all activity, but still binds to DNA. |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Nitroso-1,2-benzopyrone primarily used for?
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6-Nitroso-1,2-benzopyrone is primarily used as an inhibitor of ADP-ribosyltransferase enzymes in biochemical research, aiding in the study of enzyme mechanisms and DNA interactions.
What is the CAS number and molecular formula for 6-Nitroso-1,2-benzopyrone?
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The CAS number for 6-Nitroso-1,2-benzopyrone is 130506-22-8, and its molecular formula is C9H5NO3.
What grade and purity does Tech Serve Solutions supply for 6-Nitroso-1,2-benzopyrone?
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Tech Serve Solutions supplies this compound for research purposes. The specific assay or grade is available upon request, and it is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 6-Nitroso-1,2-benzopyrone be handled and stored?
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According to the supplied data, 6-Nitroso-1,2-benzopyrone has a WGK Germany rating of 3, indicating it is hazardous. It should be stored at -20°C and handled with appropriate personal protective equipment in a well-ventilated area.
Is 6-Nitroso-1,2-benzopyrone a controlled substance?
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The provided data does not indicate that 6-Nitroso-1,2-benzopyrone is a controlled substance.
How can I request a sample or quote for 6-Nitroso-1,2-benzopyrone?
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To request a sample or quote for 6-Nitroso-1,2-benzopyrone, please contact the Tech Serve Solutions sales team through our website or by phone.
How is 6-Nitroso-1,2-benzopyrone packed and shipped?
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6-Nitroso-1,2-benzopyrone is carefully packed according to industry standards for chemical reagents and is exported globally by Tech Serve Solutions. Specific shipping details can be provided upon inquiry.
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