6-Methyl-2-pyridylzinc bromide solution
6-Methyl-2-pyridylzinc bromide solution (CAS: 308795-98-4) is a versatile organozinc reagent with a molecular weight of 237.41 g/mol. Supplied as a 0.5 M solution in THF, it is an indispensable tool in organic synthesis, particularly for the formation of carbon-carbon bonds. Its applications span the creation of complex heteroaromatic compounds, making it valuable in pharmaceutical and materials science research.
Cross-Coupling Reactions
This organozinc reagent is extensively used in various cross-coupling reactions, such as Negishi couplings, to introduce the 6-methyl-2-pyridyl moiety into organic frameworks. This is crucial for building complex molecular architectures.
Heteroaryl Synthesis
It serves as a key building block for the synthesis of substituted pyridines and other heteroaromatic systems. These structures are prevalent in many biologically active molecules and functional materials.
Pharmaceutical Intermediate Synthesis
The ability to precisely functionalise pyridine rings makes this reagent valuable in the multi-step synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
Materials Science
6-Methyl-2-pyridylzinc bromide can be employed in the development of novel organic materials, including ligands for catalysis or components for optoelectronic devices, due to the unique electronic properties of the pyridine ring.
| Molecular weight | 237.41 |
|---|---|
| Empirical formula | C6H6BrNZn |
| Density | 0.996 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Methyl-2-pyridylzinc bromide solution used for?
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This organozinc reagent is primarily used in organic synthesis for cross-coupling reactions, particularly in the construction of heteroaromatic compounds like substituted pyridines, and as an intermediate in pharmaceutical synthesis.
What is the CAS number and formula for 6-Methyl-2-pyridylzinc bromide solution?
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The CAS number is 308795-98-4. The empirical formula (Hill notation) is C6H6BrNZn.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Methyl-2-pyridylzinc bromide solution at a concentration of 0.5 M in THF. We do not specify USP, BP, or EP grades unless explicitly stated in the product data.
What are the safety and handling considerations for this product?
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This product is highly flammable (H225), causes serious eye irritation (H319), and may cause respiratory irritation (H335). It is also suspected of causing cancer (H351) and may form explosive peroxides. Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources. Store at 2-8°C.
How is this chemical packed, shipped, and exported?
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This reagent is supplied as a solution in THF, a flammable solvent. It is shipped and exported in accordance with relevant dangerous goods regulations (UN 2924, 8(3), PGII).
How can I request a sample or quote for 6-Methyl-2-pyridylzinc bromide solution?
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Please contact our sales team via the website or direct email to request a sample or a quotation. Provide your contact details and the required quantity.
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