6-Methoxy-8-nitroquinoline
6-Methoxy-8-nitroquinoline (CAS: 85-81-4), with the molecular formula C10H8N2O3, is a valuable heterocyclic building block. This compound serves as a key intermediate in various chemical syntheses, particularly in the preparation of pharmaceutical-related molecules. Its utility is demonstrated in the creation of primaquine metabolites and related amino- and hydroxylaminoquinoline derivatives, making it an important reagent for organic synthesis and medicinal chemistry research.
Synthesis of Primaquine Metabolites
6-Methoxy-8-nitroquinoline is utilized in the laboratory synthesis of 6-methoxy-8-aminoquinoline, a known metabolite of the antimalarial drug primaquine. It also serves as a precursor for 6-methoxy-8-hydroxylaminoquinoline.
Preparation of Substituted Quinolines
The compound is employed in organic synthesis to create 2-substituted and 2,5-disubstituted 6-methoxy-8-nitroquinolines. These derivatives can be further investigated for their chemical and biological properties.
General Chemical Synthesis
As a functionalized quinoline derivative, 6-Methoxy-8-nitroquinoline acts as a versatile building block in complex organic molecule construction. Its reactive sites allow for diverse chemical transformations.
| Molecular weight | 204.18 |
|---|---|
| Empirical formula | C10H8N2O3 |
| Assay | 99% |
| Application | 6-Methoxy-8-nitroquinoline was used in the synthesis of: • 6-methoxy-8-aminoquinoline, metabolite of primaquine1• 6-methoxy-8-hydroxylaminoquinoline1• 2-substituted/2,5-disubstituted-6-methoxy-8-nitroquinolines2 |
| Melting point | 158-160 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38-40 |
| Safety statements (S) | 26-27-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Methoxy-8-nitroquinoline used for?
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6-Methoxy-8-nitroquinoline is primarily used as a chemical intermediate in organic synthesis, notably for preparing metabolites of primaquine such as 6-methoxy-8-aminoquinoline and 6-methoxy-8-hydroxylaminoquinoline, and for the synthesis of various substituted quinoline derivatives.
What are the CAS number and molecular formula for 6-Methoxy-8-nitroquinoline?
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The CAS number for 6-Methoxy-8-nitroquinoline is 85-81-4, and its molecular formula is C10H8N2O3.
What grade and purity does Tech Serve Solutions supply for 6-Methoxy-8-nitroquinoline?
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Tech Serve Solutions supplies 6-Methoxy-8-nitroquinoline with a minimum purity of 99% (assay). This product is supplied for research and laboratory use. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeial grade.
What are the safety and handling precautions for 6-Methoxy-8-nitroquinoline?
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6-Methoxy-8-nitroquinoline is classified with GHS07 and GHS08 symbols and a Warning signal word. It carries hazard statements H302, H312, H315, H319, H332, H335, and H351, indicating it is harmful if swallowed, in contact with skin, or inhaled; causes skin and serious eye irritation; and may cause drowsiness or dizziness, and is suspected of causing cancer. Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection (e.g., N100 or P3 filters), is required. Handle only in a well-ventilated area.
How is 6-Methoxy-8-nitroquinoline packed and shipped?
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Tech Serve Solutions packs and ships 6-Methoxy-8-nitroquinoline in compliance with all relevant regulations for fine chemical export. Specific packaging details are available upon request.
How can I request a sample or quote for 6-Methoxy-8-nitroquinoline?
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To request a sample or a quote for 6-Methoxy-8-nitroquinoline, please contact our sales department via the website or email, providing your contact details and intended use.
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