6-Cyano-2-naphthol
6-Cyano-2-naphthol (CAS: 52927-22-7; Formula: NCC10H6OH) is a key organic building block with a molecular weight of 169.18 g/mol. This nitrile and nitrogen compound is primarily utilised as a reactant in various catalysed organic synthesis reactions. Its defined structure and chemical properties make it valuable in the development of more complex molecules within the pharmaceutical and chemical industries.
- IUPAC
- 2-Cyano-6-hydroxynaphthalene,2-Hydroxy-6-naphthonitrile,2-Cyano-6-naphthol,6-Cyano-2-hydroxynaphthalene,6-Hydroxy-2-naphthalenecarbonitrile,6-Hydroxy-2-naphthonitrile
- Synonyms
- 2-Cyano-6-hydroxynaphthalene2-Hydroxy-6-naphthonitrile2-Cyano-6-naphthol6-Cyano-2-hydroxynaphthalene6-Hydroxy-2-naphthalenecarbonitrile6-Hydroxy-2-naphthonitrile

Palladium-Catalyzed Reductions
6-Cyano-2-naphthol serves as a substrate in palladium-catalyzed reduction reactions, enabling specific chemical transformations in organic synthesis pathways.
Nickel-Catalyzed Cross-Coupling
This compound is employed as a reactant in nickel-catalyzed cross-coupling reactions, facilitating the formation of carbon-carbon bonds in complex molecular assemblies.
Palladium-Catalyzed Heck Reactions
It functions as a participant in palladium-catalyzed Heck reactions, a widely used method for creating substituted alkenes.
| Molecular weight | 169.18 |
|---|---|
| Linear formula | NCC10H6OH |
| Assay | 97% |
| Application | Reactant for:• Palladium-catalyzed reduction1• Nickel-catalyzed cross-coupling reactions2• Palladium-catalyzed Heck reactions3 |
| Melting point | 165.5-170.5 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Cyano-2-naphthol primarily used for?
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6-Cyano-2-naphthol is used as a reactant in palladium-catalyzed reductions, nickel-catalyzed cross-coupling reactions, and palladium-catalyzed Heck reactions.
What are the CAS number and chemical formula for 6-Cyano-2-naphthol?
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The CAS number for 6-Cyano-2-naphthol is 52927-22-7, and its chemical formula is NCC10H6OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Cyano-2-naphthol with an assay of 97%. This product is not represented as USP, BP, EP, or pharmacopoeia grade.
How should 6-Cyano-2-naphthol be handled safely?
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According to GHS, 6-Cyano-2-naphthol is a Warning substance (H315, H319, H335) causing skin irritation, serious eye irritation, and respiratory irritation. Handle with a dust mask type N95, eyeshields, and gloves in a well-ventilated area. Avoid breathing dust.
How is 6-Cyano-2-naphthol packed, shipped, and exported?
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Tech Serve Solutions professionally packs, ships, and exports 6-Cyano-2-naphthol globally, adhering to all relevant regulations for chemical transport.
How can I request a sample or quote for 6-Cyano-2-naphthol?
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To request a sample or a quotation for 6-Cyano-2-naphthol, please contact the Tech Serve Solutions sales team via our website or direct inquiry.
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