6-Chloropyridine-2-carbonitrile
6-Chloropyridine-2-carbonitrile (CAS 33252-29-8), with the molecular formula C6H3ClN2 and a molecular weight of 138.55 g/mol, is a halogenated heterocyclic building block. This compound serves as a valuable substrate in organic synthesis, notably in palladium-catalysed coupling reactions. Its well-defined structure and reactivity make it a key intermediate for constructing more complex molecules within the pharmaceutical and chemical industries.
- IUPAC
- 2-Chloro-6-cyanopyridine,6-Chloropicolinonitrile
- Synonyms
- 2-Chloro-6-cyanopyridine6-Chloropicolinonitrile
Negishi Coupling Reactions
Serves as a substrate in Negishi coupling reactions. It reacts with arylzinc halides, catalysed by palladium-NHC complexes such as PEPPSI-Ipr, to form new carbon-carbon bonds.
Organic Synthesis Intermediate
A versatile building block for the synthesis of various organic compounds. Its functional groups allow for further chemical transformations, leading to diverse molecular structures.
Pharmaceutical Research
Used in the development of novel pharmaceutical agents. Its pyridine core and reactive nitrile and chloro substituents are useful for medicinal chemistry programmes.
| Molecular weight | 138.55 |
|---|---|
| Empirical formula | C6H3ClN2 |
| Assay | 96% |
| Application | Substrate used in a Negishi coupling reaction with an arylzinc halide catalyzed by Pd-NHC (PEPPSI-Ipr, Catalog No. 668032).1 |
| Melting point | 85-89 °C |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Chloropyridine-2-carbonitrile used for?
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6-Chloropyridine-2-carbonitrile is primarily used as a substrate in organic synthesis, particularly in palladium-catalysed cross-coupling reactions like the Negishi coupling. It acts as a building block for creating more complex organic molecules, including those relevant to pharmaceutical research.
What is the CAS number and molecular formula?
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The CAS number for 6-Chloropyridine-2-carbonitrile is 33252-29-8, and its molecular formula is C6H3ClN2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Chloropyridine-2-carbonitrile with an assay of 96%. This is a technical grade material and is not represented as USP, BP, or EP grade.
How should 6-Chloropyridine-2-carbonitrile be handled?
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Handling requires caution due to its hazards. It is harmful if swallowed, causes skin irritation, serious eye damage, and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, face shields, and gloves, must be worn. Ensure adequate ventilation, use P261, P280, P301+P310, and P305+P351+P338 precautions.
Is this chemical a controlled substance?
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The provided data does not indicate that 6-Chloropyridine-2-carbonitrile is a controlled substance.
How is this chemical shipped and exported?
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6-Chloropyridine-2-carbonitrile is classified under UN 2811, hazard class 6.1, with a packing group of III. TSS is experienced in exporting chemicals globally, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote?
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To request a sample or a quotation for 6-Chloropyridine-2-carbonitrile, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.
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