6-(Chloromethyl)uracil
6-(Chloromethyl)uracil (CAS: 18592-13-7; Formula: C5H5ClN2O2; MW: 160.56) is a halogenated heterocyclic building block utilised in organic synthesis. Its structure, featuring a reactive chloromethyl group on the uracil core, facilitates its incorporation into more complex molecular architectures. This compound serves as a key intermediate in the development of pteridine derivatives with potential anticancer activity and substituted uracil pyridinium compounds investigated as thymidine phosphorylase inhibitors.
Synthesis of Pteridine Compounds
6-(Chloromethyl)uracil is employed in the synthetic pathways leading to pteridine derivatives, which are being explored for their potential as anticancer agents.
Preparation of Substituted Uracil Pyridinium Compounds
This chemical is a precursor for substituted uracil pyridinium compounds. These compounds have been investigated for their inhibitory effects on thymidine phosphorylase.
Intermediate in Halogenated Heterocycle Synthesis
As a halogenated heterocyclic building block, 6-(Chloromethyl)uracil is useful in the construction of various complex organic molecules requiring a functionalised pyrimidine ring.
| Molecular weight | 160.56 |
|---|---|
| Empirical formula | C5H5ClN2O2 |
| Assay | 98% |
| Application | 6-(Chloromethyl)uracil was used in the synthesis of:• 5-bromo-6-(chloromethyl)uracil1• pteridine compounds, potential anticancer agents2• substituted uracil pyridinium compounds, potential inhibitors of thymidine phosphorylase3 |
| Melting point | 257 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-(Chloromethyl)uracil used for?
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6-(Chloromethyl)uracil is used as a building block in organic synthesis, particularly for the preparation of pteridine compounds with potential anticancer activity and substituted uracil pyridinium compounds investigated as thymidine phosphorylase inhibitors.
What is the CAS number and chemical formula for 6-(Chloromethyl)uracil?
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The CAS number for 6-(Chloromethyl)uracil is 18592-13-7, and its chemical formula is C5H5ClN2O2.
What grade and purity does Tech Serve Solutions supply for 6-(Chloromethyl)uracil?
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Tech Serve Solutions supplies 6-(Chloromethyl)uracil with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 6-(Chloromethyl)uracil be handled safely?
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6-(Chloromethyl)uracil is classified as a warning substance. It may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used when handling. Work in a well-ventilated area or fume hood.
Is 6-(Chloromethyl)uracil available for international export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 6-(Chloromethyl)uracil.
How can I request a sample or quote for 6-(Chloromethyl)uracil?
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To request a sample or obtain a quote for 6-(Chloromethyl)uracil, please contact our sales team through the website or by phone.
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