6-(5H)-Phenanthridinone
6-(5H)-Phenanthridinone (CAS: 1015-89-0) is a nitrogen-containing heterocyclic compound with the molecular formula C13H9NO and a molecular weight of 195.22 g/mol. This technical grade chemical serves as a key reactant in various organic syntheses, including the preparation of phenanthridine sulfonamides and coupling reactions. It is also employed in research for developing biologically active molecules, such as potassium channel inhibitors and HIV-1 integrase inhibitors.
- IUPAC
- NSC 11021,NSC 40943,NSC 61083
Synthesis of Phenanthridine Derivatives
6-(5H)-Phenanthridinone is a precursor in the synthesis of 5,6-dihydrophenanthridine sulfonamides. It also participates in oxidative coupling reactions, for instance, with diphenylacetylene.
Development of Bioactive Molecules
This compound is instrumental in the research and development of molecules with potential pharmacological activity, including inhibitors targeting potassium channels (KV1.3 and IK-1) and HIV-1 integrase.
Organic Synthesis Reagent
It acts as a versatile reactant in organic chemistry, for example, in direct copper acetate-catalyzed N-cyclopropylation of cyclic amides, enabling access to complex heterocyclic structures.
| Molecular weight | 195.22 |
|---|---|
| Empirical formula | C13H9NO |
| Grade | technical grade |
| Application | Reactant involved in:• Synthesis of 5,6-dihydrophenanthridine sulfonamides1• Oxidative coupling with diphenylacetylene2• Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides3Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:• Potassium channel KV1.3 and IK-1 inhibitors4• HIV-1 integrase inhibitors5 |
| Melting point | 290-292 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PARP1(142) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-(5H)-Phenanthridinone used for?
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6-(5H)-Phenanthridinone is used as a reactant in organic synthesis, particularly for creating phenanthridine sulfonamides, in oxidative coupling reactions, and in the development of biologically active molecules like potassium channel and HIV-1 integrase inhibitors. It also features in N-cyclopropylation reactions.
What are the CAS number and molecular formula for 6-(5H)-Phenanthridinone?
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The CAS number for 6-(5H)-Phenanthridinone is 1015-89-0, and its molecular formula is C13H9NO.
What grade and purity does Tech Serve Solutions supply for 6-(5H)-Phenanthridinone?
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Tech Serve Solutions supplies 6-(5H)-Phenanthridinone in technical grade. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should 6-(5H)-Phenanthridinone be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance has a WGK (German water hazard class) of 3.
Is 6-(5H)-Phenanthridinone a controlled substance?
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The provided data does not indicate that 6-(5H)-Phenanthridinone is a controlled substance. Always adhere to local regulations.
How can I request a sample or quote for 6-(5H)-Phenanthridinone?
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To request a sample or a quote for 6-(5H)-Phenanthridinone, please use the contact form on our website or contact our sales department directly.
How is 6-(5H)-Phenanthridinone packed and shipped?
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6-(5H)-Phenanthridinone is carefully packed according to industry standards to ensure safe transport and is exported globally by Tech Serve Solutions.
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