5-(Trifluoromethoxy)isatin
5-(Trifluoromethoxy)isatin (CAS: 169037-23-4), with the molecular formula C9H4F3NO3 and a molecular weight of 231.13 g/mol, is a specialised chemical intermediate. It serves as a key building block in organic synthesis, particularly for the development of novel heterocyclic compounds. Its applications span pharmaceutical research, enabling the creation of potential therapeutic agents.
- IUPAC
- 5-(Trifluoromethoxy)indoline-2,3-dione
- Synonyms
- 5-(Trifluoromethoxy)indoline-2,3-dione
Preparation of Fluorinated Indolinonylidene-hydrazine-carbothioamides
This compound acts as a reactant in condensation reactions with thiosemicarbazides to produce fluorinated indolinonylidene-hydrazine-carbothioamides. These derivatives may find applications in medicinal chemistry research.
Synthesis of Oxindole Derivatives for Kinase Inhibition
5-(Trifluoromethoxy)isatin is employed in the synthesis of oxindole derivatives. These compounds have been investigated for their potential as TAk1 kinase inhibitors, relevant in targeted therapies.
Development of Isatin Thiosemicarbazone Derivatives
The chemical is a precursor for preparing isatin thiosemicarbazones through condensation with thiosemicarbazones. These resulting compounds have shown inhibitory activity against herpes simplex virus (HSV).
Synthesis of Ortho Disubstituted Biphenyls
This isatin derivative serves as a reactant in the synthesis pathways leading to ortho disubstituted biphenyl structures, valuable motifs in various chemical syntheses.
Preparation of Indolinon-spirothiazolidinones
It is used to synthesise indolinon-spirothiazolidinones, which are explored for their selective inhibitory properties against Mycobacterium tuberculosis protein tyrosine phosphatase B.
Synthesis of 3-Substituted 2-Indolinone RET Kinase Inhibitors
5-(Trifluoromethoxy)isatin is a reactant in the synthesis of 3-substituted 2-indolinone derivatives investigated as inhibitors of RET kinase.
| Molecular weight | 231.13 |
|---|---|
| Empirical formula | C9H4F3NO3 |
| Assay | 98% |
| Application | Reactant for preparation of (fluorinated-indolinonylidene)-hydrazine-carbothioamides by condensation with thiosemicarbazides1Reactant for preparation of oxindole derivatives as TAk1 kinase inhibitors2Reactant for preparation of isatin thiosemicarbazones via condensation with thiosemicarbazones as herpes simplex virus (HSV) inhibitors3Reactant for synthesis of ortho disubstituted biphenyls4Reactant for preparation of indolinon-spirothiazolidinones as selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B5Reactant for synthesis of 3-substituted 2-indolinone RET kinase inhibitors6Reactant for preparation of indolone acetamides as antiseizure agents7 |
| Melting point | 170-172 °C(lit.) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-(Trifluoromethoxy)isatin used for?
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5-(Trifluoromethoxy)isatin is primarily used as a building block in organic synthesis for creating complex heterocyclic compounds, with applications in the development of potential therapeutic agents, including kinase inhibitors and antiviral compounds.
What is the CAS number and molecular formula for 5-(Trifluoromethoxy)isatin?
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The CAS number for 5-(Trifluoromethoxy)isatin is 169037-23-4, and its molecular formula is C9H4F3NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-(Trifluoromethoxy)isatin with a minimum purity of 98%. This product is intended for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
How is 5-(Trifluoromethoxy)isatin handled and stored?
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5-(Trifluoromethoxy)isatin is classified under WGK 2 in Germany, indicating it is hazardous to water. Handle with appropriate personal protective equipment in a well-ventilated area. Store in a cool, dry place away from incompatible materials.
Can Tech Serve Solutions export 5-(Trifluoromethoxy)isatin?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 5-(Trifluoromethoxy)isatin, serving customers worldwide.
How can I request a quotation or sample of 5-(Trifluoromethoxy)isatin?
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Please contact our sales department via the website or email to request a quotation or to inquire about obtaining a sample of 5-(Trifluoromethoxy)isatin.
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