5-Nitrobenzofuran-2-carboxylic acid
5-Nitrobenzofuran-2-carboxylic acid (CAS: 10242-12-3), with the molecular formula C9H5NO5 and a molecular weight of 207.14, is a heterocyclic organic compound. It serves as a key building block and reactant in complex chemical synthesis. Its applications span the preparation of advanced pharmaceutical intermediates, including potential antitumor agents and analogues of known antibacterial compounds, as well as its use in the development of receptor antagonists.
- IUPAC
- 2-Carboxy-5-nitrobenzofuran,5-Nitro-2-benzofurancarboxylic acid
Preparation of Arylarylamidobenzofurans
Utilised in a multi-step synthesis involving Curtius rearrangement, bromination, and Suzuki reaction to form complex arylarylamidobenzofuran structures.
Synthesis of Antibacterial Analogues
Serves as a precursor in the synthesis and subsequent antibacterial evaluation of novel compounds based on the nitazoxanide structure.
Development of Melanin-Concentrating Hormone Receptor 1 Antagonists
Employed in the synthetic pathway for creating Melanin-Concentrating Hormone Receptor 1 antagonists, relevant in pharmacological research.
Synthesis of Antitumor Agents
Incorporated into the synthesis of benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogs, investigated for their antitumor properties.
| Molecular weight | 207.14 |
|---|---|
| Empirical formula | C9H5NO5 |
| Assay | 97% |
| Application | Reactant for:• Preparation of arylarylamidobenzofurans via Curtius rearrangement followed by bromination and Suzuki reaction1• Synthesis and antibacterial evaluation of nitazoxanide-based analogs2• Preparation of Melanin-Concentrating Hormone Receptor 1 antagonist3• Synthesis of benzoyl and cinnamoyl nitrogen mustard derivatives of benzoheterocyclic analogs of tallimustine as antitumor agents4 |
| Melting point | 279-284 °C |
Hazard statements
- H302Harmful if swallowed
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 22-36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Nitrobenzofuran-2-carboxylic acid used for?
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5-Nitrobenzofuran-2-carboxylic acid is used as a reactant and building block in organic synthesis, notably for the preparation of arylarylamidobenzofurans, nitazoxanide-based antibacterial analogues, Melanin-Concentrating Hormone Receptor 1 antagonists, and antitumor agents.
What are the CAS number and molecular formula for 5-Nitrobenzofuran-2-carboxylic acid?
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The CAS number is 10242-12-3 and the molecular formula is C9H5NO5.
What grade and purity does Tech Serve Solutions supply for 5-Nitrobenzofuran-2-carboxylic acid?
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Tech Serve Solutions supplies 5-Nitrobenzofuran-2-carboxylic acid with a minimum assay of 97%. This product is intended for research and chemical synthesis and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
What are the primary safety concerns when handling 5-Nitrobenzofuran-2-carboxylic acid?
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Warning: This compound is harmful if swallowed (H302) and causes serious eye irritation (H319). Handle with appropriate personal protective equipment in a well-ventilated area. In case of eye contact, rinse cautiously with water for several minutes and seek medical advice if irritation persists.
Is 5-Nitrobenzofuran-2-carboxylic acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 5-Nitrobenzofuran-2-carboxylic acid, to research institutions and chemical manufacturers worldwide.
How can I request a sample or a quote for 5-Nitrobenzofuran-2-carboxylic acid?
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To request a sample or a quotation, please contact our sales department via the website or provide your inquiry details through the 'Contact Us' form, specifying the product name and CAS number.
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