5-Methylisoxazole-3-carboxylic acid
5-Methylisoxazole-3-carboxylic acid (CAS: 3405-77-4), with the molecular formula C5H5NO3 and a molecular weight of 127.10 g/mol, is a versatile heterocyclic building block. This compound serves as a key reactant in various organic synthesis applications, including click/aza-Michael esterification reactions and the preparation of complex heterocyclic systems. It is primarily utilised in chemical synthesis and research laboratories for the development of novel compounds.
- IUPAC
- 3-Carboxy-5-methylisoxazole,5-Methyl-3-isoxazolecarboxylic acid
- Synonyms
- 3-Carboxy-5-methylisoxazole5-Methyl-3-isoxazolecarboxylic acid
Esterification Reactions
5-Methylisoxazole-3-carboxylic acid is employed as a reactant in click/aza-Michael esterification reactions, facilitating the formation of ester linkages in organic synthesis.
Melanoma Research
It is used in the preparation of aminopyrazole amide derivatives, which have been investigated for their potential as Raf kinase inhibitors in melanoma cell studies.
Heterocycle Synthesis
The compound participates in chain heterocyclization reactions for the preparation of trifluoromethoxyphenyl(thiazolyl)pyrroles and other polyfunctionalized pyrrole derivatives.
| Molecular weight | 127.10 |
|---|---|
| Empirical formula | C5H5NO3 |
| Application | Reactant for:• Click/aza-Michael or Click/oligomeric alkyl carbodiimide esterification reactions1• Preparation of aminopyrazole amide derivatives as Raf kinase inhibitors in melanoma cells2• Preparation of trifluoromethoxyphenyl(thiazolyl)pyrroles and other heterocycle-bearing polyfunctionalized pyrroles via chain heterocyclization3 |
| Melting point | 106-110 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Methylisoxazole-3-carboxylic acid used for?
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5-Methylisoxazole-3-carboxylic acid is a building block used in chemical synthesis, including click/aza-Michael esterification reactions and the preparation of various heterocyclic compounds and potential kinase inhibitors.
What are the CAS number and formula for 5-Methylisoxazole-3-carboxylic acid?
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The CAS number is 3405-77-4, and the empirical formula is C5H5NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Methylisoxazole-3-carboxylic acid primarily for research and chemical synthesis purposes. Specific grades and purities should be confirmed with a quote request, as TSS does not represent this product as USP, BP, or EP grade.
What are the safety and handling recommendations for this chemical?
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Handling requires eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance is classified with WGK Germany 3, indicating a high hazard to water.
How is 5-Methylisoxazole-3-carboxylic acid packed and exported?
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Tech Serve Solutions offers this chemical for global export, with packaging suitable for safe transport of laboratory reagents and fine chemicals.
How can I request a quote or sample?
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To request a quote or sample of 5-Methylisoxazole-3-carboxylic acid, please contact our sales team through the website or direct inquiry channels.
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