5-Hexynenitrile
5-Hexynenitrile (CAS: 14918-21-9; Formula: HC≡C(CH2)3CN; MW: 93.13) is a versatile organic compound featuring both a terminal alkyne and a nitrile functional group. This unique structure makes it a valuable building block in organic synthesis. It is primarily utilised in the preparation of more complex molecules, including heterocyclic compounds, and serves as a key intermediate in various chemical research and development applications.
- IUPAC
- 5-Cyano-1-pentyne
- Synonyms
- 5-Cyano-1-pentyne
Synthesis of Bipyridines
5-Hexynenitrile has been employed in cobalt(I)-catalyzed [2+2+2] cycloaddition reactions. This process is instrumental in the synthesis of annelated symmetric and asymmetric 3,3′-disubstituted 2,2′-bipyridines when reacted with 1,3-diynes.
Organic Building Block
As a bifunctional molecule containing both an alkyne and a nitrile, 5-Hexynenitrile serves as a useful synthon. It allows for diverse chemical transformations, enabling the construction of complex organic frameworks in research and development.
Chemical Synthesis Intermediate
This compound's reactive alkyne and nitrile groups make it a key intermediate for various synthetic pathways. It is suitable for creating novel chemical entities within research laboratories and fine chemical production.
| Molecular weight | 93.13 |
|---|---|
| Linear formula | HC≡C(CH2)3CN |
| Assay | 97% |
| Boiling point | 115-117 °C(lit.) |
| Density | 0.889 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.44(lit.) |
| Storage temperature | 2-8°C |
| Application | 5-Hexynenitrile was used in the synthesis of annelated symmetric and asymmetric 3,3′-disubstituted 2,2′-bipyridines by cobalt(I)-catalyzed [2+2+2] cycloadditions with 1,3-diynes1. |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 42 °C / 107.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22-36/37/38 |
| Safety statements (S) | 16-23-26-28-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Hexynenitrile used for?
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5-Hexynenitrile is used as a building block in organic synthesis, particularly in the preparation of annelated symmetric and asymmetric 3,3′-disubstituted 2,2′-bipyridines through cobalt(I)-catalyzed cycloaddition reactions with 1,3-diynes.
What is the CAS number and chemical formula for 5-Hexynenitrile?
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The CAS number for 5-Hexynenitrile is 14918-21-9, and its chemical formula is HC≡C(CH2)3CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Hexynenitrile at a purity of 97% (assay). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the main safety hazards associated with 5-Hexynenitrile?
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5-Hexynenitrile is a flammable liquid and vapour (H226) and is harmful if swallowed, in contact with skin, or if inhaled (H302, H312, H332). It can cause skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Always handle with appropriate personal protective equipment in a well-ventilated area.
How is 5-Hexynenitrile shipped and exported?
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5-Hexynenitrile is classified under UN 1993, C3/PGIII for transport. Tech Serve Solutions, a global supplier and exporter since 1998, adheres to all regulations for the safe packaging, shipping, and export of this chemical.
How can I request a quote or sample for 5-Hexynenitrile?
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To request a quote or a sample of 5-Hexynenitrile, please contact our sales department through the enquiry form or by calling our main office. Please provide your contact details and the quantity required.
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