5-Bromouracil
5-Bromouracil (CAS: 51-20-7), with the molecular formula C4H3BrN2O2 and a molecular weight of 190.98 g/mol, is a pyrimidine derivative. This compound serves as a valuable building block in organic synthesis and is employed in biochemical research. Tech Serve Solutions supplies 5-Bromouracil with an assay of ≥95.0% (HPLC), suitable for various laboratory and synthesis applications.
- IUPAC
- 5-Bromo-2,4-dihydroxypyrimidine
Synthesis of Orotic Acid Derivatives
5-Bromouracil has been utilised in the preparation of N-substituted orotic acid derivatives, contributing to the synthesis of novel chemical entities.
Analytical Chemistry Standard
This compound has been employed as an internal standard in the high-performance liquid chromatography (HPLC) method for the simultaneous determination of 5-fluorouracil and its prodrug, tegafur, in biological samples like dog plasma.
Heterocyclic Building Block
As a halogenated heterocycle, 5-Bromouracil functions as a versatile building block for constructing more complex heterocyclic structures in organic synthesis.
| Molecular weight | 190.98 |
|---|---|
| Empirical formula | C4H3BrN2O2 |
| Assay | ≥95.0% (HPLC) |
| Application | 5-Bromouracil was used in the synthesis of N-substituted orotic acid derivatives1. It was also used as internal standard in simultaneous determination of 5-fluorouracil and its prodrug, tegafur in dog plasma by HPLC2. |
| Melting point | >300 °C(lit.)~304 °C (dec.) |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Bromouracil used for?
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5-Bromouracil is used in chemical synthesis, particularly for preparing N-substituted orotic acid derivatives and as an internal standard in analytical chemistry, for example, in the determination of 5-fluorouracil and tegafur in plasma.
What are the CAS number and formula for 5-Bromouracil?
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The CAS number for 5-Bromouracil is 51-20-7, and its empirical formula is C4H3BrN2O2.
What grade and purity does Tech Serve Solutions supply for 5-Bromouracil?
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Tech Serve Solutions supplies 5-Bromouracil with a purity of ≥95.0% as determined by HPLC. This product is supplied for research and laboratory use and is not represented as pharmacopoeia grade (e.g., USP, BP, EP).
How should 5-Bromouracil be handled safely?
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5-Bromouracil is classified with a GHS07 symbol and a Warning signal word, carrying the hazard statement H302 (Harmful if swallowed). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be worn during handling to minimise exposure.
Is 5-Bromouracil subject to any special regulations or controls?
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Based on the provided data, there is no indication that 5-Bromouracil is a controlled substance. However, users should always comply with local regulations regarding chemical handling and use.
How is 5-Bromouracil typically packed and exported?
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5-Bromouracil is carefully packed to ensure stability during transit and is exported globally by Tech Serve Solutions in compliance with international shipping regulations for chemical products.
How can I request a sample or quote for 5-Bromouracil?
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To request a sample or a quote for 5-Bromouracil, please contact the Tech Serve Solutions sales team through our website or by direct inquiry, providing your specific requirements.
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